| 彭 楠 赵彼得 郭新娜.吐温80 在深部脏器肿瘤热化疗中的应用研究[J].,2006,6(4):40-41 |
| 吐温80 在深部脏器肿瘤热化疗中的应用研究 |
| The Initial Application of Tween 80 in Thermochemotherapy of Deep Seated Tumors |
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| DOI： |
| 中文关键词: 吐温80 热疗 肿瘤 |
| 英文关键词: Tween 80 Thermotherapy Tumor treatment |
| 基金项目: |
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| 中文摘要: |
| 目的: 研究热增敏剂吐温80 在深部肿瘤热化疗中的临床应用疗效。方法: 采用吐温80 合并热化疗综合治疗晚期肿
瘤118 例, 并与同时期未采用吐温80 的热化疗组98 例进行比较。膀胱癌复发5 例, 伴腹水、腹膜转移7 例。小剂量化疗用5-
FU、丝裂霉素、顺铂等行膀胱灌注或腹腔注射, 吐温80 浓度为0. 2%。肿瘤射频热疗机, f: 41MHz。平均随访时间36 个月。结果:
复发性膀胱癌完全缓解率达60%, 血尿消失, 3 例在12~ 34 月随访期间膀胱镜检查未复发; 伴腹水者完全缓解率达85. 7% ( CR6/
7) , 中位生存期8. 5 月, 腹痛、腹胀、便血等消失。治疗未引起恶心、呕吐等明显的消化道症状, 肝、肾和骨髓功能损害。结论: 在
肿瘤的热化疗中, 合用吐温80 不仅可以降低化疗药物的剂量, 而且降低热疗时的温度, 减少毒副作用, 改善症状和体征。 |
| 英文摘要: |
| Objective: To observe the thermal sensitization effect of Tween 80. Methods: 12 patients with advanced stage malignant
tumors were given thermochemotherapy( TCT) combined with Tween 80. Five of them were bladder cancer and 7 had intraperitoneal metastases
with malignant ascites. After irrigation of bladder and intraperitoneal injection with solution containing small amount 5- FU and mitomycin and
cisplatin, local thermotherapy with RF heating machine ( f: 41MHz) were carried out, Tween 80 was added into the solution with final concentration
of 0. 2%. Results: For recurred bladder cancer, complete remission rate( CRR) was 60% with disappeared hemourine and 12- 34 months of
follow- up revealed no recurrence in 3 cases. For peritoneal metastases, CRR was 85. 7%of patients with a median survival of 8. 5 months, abdominal
pain and distension and bloody stool disapeared. No obvious nausea, vomiting, liver, renal and myeloid functional lesion were observed
during the treatment. Conclusions: In TCT of malignant tumors, combination of Tween 80 can not only reduce the dosage of chemical drugs but
also lower the therapeutic temperature and tox icity. |
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