| 丁立新 刘 莉.腹部恒磁场作用对大鼠药物性胃损伤的治疗机制探讨[J].,2006,6(2):27-28 |
| 腹部恒磁场作用对大鼠药物性胃损伤的治疗机制探讨 |
| A Study of Mechanism of the Therapeutic Effectiveness of Static MagneticFields on Acute Gastric Injuries by Indomethacin in Rats |
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| 中文关键词: 大鼠 恒磁场 急性胃损伤 内皮素 一氧化氮 谷胱甘肽过氧化物酶 超氧化物岐化酶 |
| 英文关键词: Static magnetic field Rat Acute gastric injury ET NO GSH- Px SOD |
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| 中文摘要: |
| 目的: 观察腹部恒磁场治疗急性药物性胃损伤模型的同时, 大鼠胃粘膜组织内皮素1( endothelin- 1, ET- 1) 、一氧化
氮( nitric oxide, NO) 、谷胱甘肽过氧化物酶( glutathione peroxidase, GSH- Px) 及超氧化物岐化酶( superox ide dismutase, SOD) 的水平,
探讨磁场治疗胃损伤的作用机制。方法: 10 只健康SD 大鼠, 在Indomethacin 胃灌注法复制急性胃损伤模型后, 以钡铁氧体恒磁场
( 表面磁强度为1300- 1600GS) 作用大鼠腹部3 小时, 观察胃损伤指数及病理损伤积分, 同时对胃粘膜组织中ET- 1、NO、GSH - Px
及SOD 水平进行比较。结果: 腹部磁场作用3 小时后, 大鼠胃损伤指数及病理损伤积分均显著减轻( p 均< 0. 05) ; 胃粘膜组织内
ET- 1、NO 及GSH- Px 水平均无显著改变( p 均> 0. 05) , SOD 含量较对照组均明显升高( p< 0. 05) 。结论: 恒磁场( 1300- 1600GS)
腹部作用3 小时, 大鼠急性胃损伤程度可明显减轻, 磁场对胃粘膜组织内自由基的影响可能参与其作用机制。 |
| 英文摘要: |
| Objective: To observe the changes in levels of endothelin- 1( ET- 1) , nitric ox ide( NO) , glutathione peroxidase( GSH- Px )
and superoxide dismutase( SOD) in rat gastric mucosa, and the therapeutic effects of static magnetic field exposure to rat abdomens on acute gastric
mucosal injuries induced by indomethacin as well, and to elucidate the mechanism of magnetotherapy to acute gastric injuries in rats. Methods:
20 healthy SD rats were randomly divided into magnetotherapy group and control group. After acute gastric injury models were copied in the
rats with gastricgavage of indomethacin, their abdomens were exposed to the static magnetic field of BaFe12O19 with magnetic strength 1300-
1600Gs for 3 hours. Gastric injury index, pathological diagnosis integral, and the levels of ET- 1, NO, GSH- Px and SOD in rat gastric mucosa
were measured. Results: After 3 hours of Static magnetic field exposure to rats. abdomens, there were no significant changes in gastric injury indexes
and pathological diagnosis integrals( p both< 0. 05) , the levels of ET- 1, NO and GSH- Px in gastric mucosa( p both> 0. 05) , however,
the level of SOD in the magnetotherapy group was higher than that in the control group( p < 0. 05) . Conclusion: The mechanism of therapeutic
effection of static magnetic fields on acute gastric injuries by indomethacin might be involved in the influence of magnetic fields on free radicals in
tissues. |
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