| 张沪生 邓仁清.超低频脉冲磁场诱导癌细胞凋亡机理研究[J].,2006,6(2):13-14 |
| 超低频脉冲磁场诱导癌细胞凋亡机理研究 |
| Mechanism Studies on Ultralow Frequency Pulsed Magnetic Field Inducing Apoptosis of Cancer Cell |
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| DOI： |
| 中文关键词: 磁场 癌 细胞凋亡 膜电位 洛仑兹力 细胞膜和核膜上的空洞 |
| 英文关键词: magnetic field cancer cell apoptosis membrane potentials Lorentz force role on cellular and nuclear membrane |
| 基金项目:国家自然科学基金资助项目( No. 39870823) |
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| 中文摘要: |
| 我们研究超低频脉冲磁场( 峰值0. 6~ 2. 0T, 梯度10~ 100T#m- 1, 脉冲宽度20~ 200ms, 重复频率0. 16~ 1. 34HZ) 作用于
鼠S- 180 肉瘤。在电镜下观察到肉瘤细胞程序性死亡的许多特征。这一磁场引起约1. 5mv 的跨膜电位变化, 导致钙离子Ca2+
内流, 促使癌细胞凋亡。磁场对运动电荷的洛仑兹力使运动的带电粒子束缚在拉莫尔( Larmor) 半径以内, 影响正负带电离子对细
胞膜和核膜的渗透能力, 甚至在膜上形成空洞。 |
| 英文摘要: |
| We studied the effects of ultralow frequency pulsed magnetic field ( with maximum intensity of 0. 6~ 2. 0T, gradient of 10~
100 T#m- 1, pulse width of 20~ 200 ms and frequency of 0. 16~ 1. 34 Hz) on S- 180 sarcomas in mice. With a electron microscope, we found
the programmed cell death ( PCD) of the sarcoma cells. We consider the mechanism is that the pulsed magnetic field causes the change of the ce-l
lular membrane potentials, then causes the calcium- ion influxing, so leads to the programmed cell death. By Lorentz force the magnetic field
keeps the moving ions within bounds of Larmor radius. Thus, penetrating capability of the positive and negative ions through the cellular and nuclear
membrane was affected, even the role on cellular and nuclear membrane formed. |
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