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目的: 探讨腹部恒磁场作用, 对大鼠急性胃损伤模型的治疗效应及其作用机制。方法: 10 只健康SD 大鼠, 以indomethacin 胃灌注法复制急性胃损伤模型, 以表面磁强度为1300- 1600GS, 钡铁氧体恒磁场作用大鼠腹部3 小时, 观察胃损伤指数及病理损伤积分, 同时对血浆中内皮素( endothelin, ET) 、一氧化氮( nitric ox ide, NO) 、谷胱甘肽过氧化物酶( GSH- Px) 及超氧化物岐化酶( SOD) 水平进行比较。结果: 恒磁场腹部作用后, 大鼠胃损伤指数及病理损伤积分较对照组均显著减轻( p 均< 0. 05) ; 血浆ET- 1 和NO 水平却无无明显改变( p 均> 0. 05) , 血GSH- Px 和SOD 含量较对照组均明显升高( p 均< 0. 05) 。结论: 腹部1300 - 1600GS 恒磁场作用3 小时, 对大鼠急性胃损伤具有明显的治疗效应, 磁场的这一效应可能与其增加血浆中清除氧自由基的 GSH- Px 和SOD 活性有关。

英文摘要:

Objective: To study the therapeutic effects and mechanism of static magnetic field exposure( SMFE) on the rats with acute indomethacin- induced gastric mocusal injuries. Methods: 20 healthy SD rats were randomly divided into two groups: magnetotherapy group( n= 10) and control group( n= 10) , and then all the rats in the two groups were respectively given indomethacin( 25mg/ kg) by gastrogavage to make acute gastric injury models. The abdomines of the rats in magnetotherapt group were exposed to the static magnetic field of BaFe12O19 with magnetic strength 1300~ 1600GS for 3 hours, gastric injury index ( GII) , pathological diagnosis integral( PDI) , the levels of endothelin( ET) , nitric oxide( NO) , glutathione peroxidase( GSH- Px) and superoxide dismutase( SOD) in the plasma of the rats were measured. Results: After undergoing SMFE, compared with control group, the GII and PDI of the rats in magnetotherapy group were obviously lower( P< 0. 05) ; there was no significant difference in the levels of plasma ET and NO( P> 0. 05) , but the levels of plasma GSH- Px and SOD were markedly higher ( P< 0. 05) . Conclusion: 3- hour exposure of static magnetic fields with magnetic strength 1300~ 1600GS had significant therapeutic effects on the rats with acute gastric injuries induced by indomethacin. The therapeutic mechanism might relate to the increasing activation of plasma GSH- Px and SOD, which could clear oxygen free radicals in gastric tissues.

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