| Objective To investigate the expression and clinical significance of serum Klotho, fibroblast growth factor 23 (FGF23) and insulin-like growth factor-1 (IGF-1) in patients with chronic periodontitis (CP). Methods 108 patients with CP (CP group) who admitted to the Department of Stomatology of our hospital from January 2022 to June 2023 were selected, and 92 patients with oral health who underwent ultrasonic tooth cleaning in our hospital during the same period were selected (control group), CP patients were divided into mild group (55 cases) and moderate to severe group (53 cases) according to the severity of CP. The levels of serum Klotho, FGF23, IGF-1, inflammatory factors interleukin (IL) -6, IL-1β and tumor necrosis factor-α (TNF-α) in CP group and control group were detected, and the periodontal clinical indicators of probing depth (PD), attachment loss (CAL) and bleeding index (BI) in CP group were examined. The correlation between serum Klotho, FGF23, IGF-1 and periodontal clinical indicators and inflammatory factors were analyzed by Pearson method. The value of serum Klotho, FGF23 and IGF-1 in the diagnosis of CP were analyzed by receiver operating characteristic (ROC) curve. Results The levels of serum FGF23, IL-6, IL-1β and TNF-α in CP group were higher than those in control group (P<0.05), and the levels of serum Klotho and IGF-1 were lower than those in control group (P<0.05). The levels of serum FGF23, IL-6, IL-1β, TNF-α, PD, CAL and BI in moderate to severe group were higher than those in mild group (P<0.05), and the levels of serum Klotho and IGF-1 were lower than those in mild group (P<0.05). The level of serum FGF23 of CP patients was positively correlated with IL-6, IL-1β, TNF-α, PD, CAL and BI (P<0.05), and the serum Klotho and IGF-1 levels were negatively correlated with IL-6, IL-1β, TNF-α, PD, CAL and BI (P<0.05). The area under the curve of serum Klotho, FGF23 and IGF-1 in the diagnosis of CP was 0.819, 0.816 and 0.861, respectively, the area under the curve of the combined diagnosis of the three indexes was 0.978, which was higher than that of the single diagnosis of each index. Conclusion The increase of serum FGF23 level, and the decrease of Klotho and IGF-1 levels in CP patients are related to the occurrence of periodontal inflammation and tissue destruction, the combined detection of serum Klotho, FGF23 and IGF-1 has high value in the diagnosis of CP. |
