| Objective To investigate the value of Pediatric early warning score (PEWS), video electroencephalogram (VEEG), neurospecific enolase (NSE) and CD4+/CD8+ ratio in evaluating the condition and predicting the prognosis of children with viral encephalitis. Methods 152 children with viral encephalitis who were admitted to the pediatric inpatient department of our hospital from March 2020 to March 2022 were selected, and they were divided into severe group (67 cases) and mild group (85 cases) according to the severity of the disease, another 72 hospitalized children without nervous system injury were selected as the control group. 2 weeks after treatment, 152 children with viral encephalitis were divided into good prognosis group (4~5 grades, 89 cases) and poor prognosis group (1~3 grades, 63 cases) according to the Glasgow Prognostic Scale (CGOS). All subjects received PEWS evaluation and VEEG examination, serum NSE level was detected, and CD4+/CD8+ ratio was calculated. The relationship between PEWS, VEEG, serum NSE, CD4+/CD8+ ratio and prognosis of children with viral encephalitis were analyzed. Results The proportion of PEWS and VEEG severe abnormality and the serum NSE level in the severe group were higher than those in the mild group and control group, and the CD4+/CD8+ ratio was lower than that in the mild group and control group (P＜0.05). The proportion of PEWS and VEEG severe abnormality and the serum NSE level in the mild group were higher than those in the control group, and the CD4+/CD8+ ratio was lower than that in the control group (P＜0.05). The proportion of PEWS, VEEG severe abnormality and serum NSE level in the poor prognosis group were higher than those in the good prognosis group, and the CD4+/CD8+ ratio was lower than that in the good prognosis group (P＜0.05). Multivariate Logistic regression analysis showed that continuous convulsion, high PEWS, VEEG severe abnormality and increased serum NSE level were risk factors for poor prognosis in children with viral encephalitis, and increased CD4+/CD8+ ratio was protective factor (P＜0.05). Combined with PEWS, VEEG, serum NSE and CD4+/CD8+ ratio, the prognostic area under curve of viral encephalitis was 0.859, which was higher than that predicted by each indicator alone. Conclusion High PEWS, VEEG severe abnormality, increased serum NSE level, and decreased CD4+/CD8+ ratio in children with viral encephalitis are associated with aggravation of the disease and poor prognosis. Combining the above four indicators is of high value to assist in predicting the prognosis of children with viral encephalitis. |
