Objective: To analyze the influencing factors of malnutrition in patients with Parkinson''s disease (PD), and to observe the effects of malnutrition on frailty, cognitive function and fall risk. Methods: 100 patients with PD who were admitted to Jiangsu Provincial People''s Hospital from March 2019 to March 2022 were selected. The nutritional status of the subjects was assessed using the Mini?Nutrition?Assessment (MNA), and 100 patients were divided into malnutrition group (n=52) and non-malnutrition group (n=48).Obtain general data of all patients , and the influencing factors of malnutrition in patients with PD were analyzed by Logistic regression. Frailty, cognitive function and fall risk were compared between the malnutrition group and non-malnutrition group. Results: Malnutrition in patients with PD was associated with age, body mass index, Hoehn-Yahr grade, residence, marital status, hemoglobin, albumin, prealbumin, daily levodopa equivalent dose (LEDDs), sleep status, anxiety status, depression status, taste disorder, swallowing disorder and decreased appetite (P<0.05). Logistic regression analysis showed that older age, Hoehn-Yahr grade III~V, deviation of sleep status, serious anxiety/depression status, taste disorder, swallowing disorder, decreased appetite and higher LEDDs were risk factors for malnutrition in patients with PD (P<0.05). The incidence of frailty in the malnutrition group was higher than that in the non-malnutrition group, and the incidence of pre-frailty and non-frailty was lower than those in the non-malnutrition group (P<0.05). The scores of Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment Scale (MOCA) in the malnutrition group were lower than those in the non-malnutrition group (P<0.05). The time of standing up and walking timing test (TUGT) and standing up test (CRT) in the malnutrition group were longer than those in the non-malnourished group, and the correct steps of walking straight gait test (TGT) were less than those in the non-malnutrition group (P<0.05). Conclusion: The risk of malnutrition in patients with PD is high, and it is affected by age, sleep status, anxiety status, depression status, Hoehn-Yahr grade, taste disorder, swallowing disorder, decreased appetite, LEDDs, and malnutrition can aggravate frailty, reduce cognitive function and increase the fall risk. |