| Objective To analyze the diagnostic value of color Doppler ultrasound combined with serum carbohydrate antigen 153 (CA153), mucin 1 (MUC1) and human growth differentiation factor 3 (GDF3) in early breast cancer. Methods 105 breast cancer patients (breast cancer group) who were admitted to our hospital from January 2019 to October 2022 were selected. In addition, 94 patients with benign breast diseases (benign group) who were admitted to our hospital during the same period and 91 healthy women in physical examination (control group) were selected. Color Doppler ultrasound and CA153, MUC1 and GDF3 levels were performed in all three groups.The clinicopathological diagnosis was taken as the gold standard, and the diagnostic value of color Doppler ultrasound, serum CA153, MUC1 and GDF3 alone and in combination in early breast cancer were analyzed. Results In the control group, the contour of bilateral mammary glands was clear, no obvious thickening was found, the gland structure was not significantly abnormal, and the echo was uniform.The ratio of aspect ratio ≥1, grade II-III blood flow grade, irregular tumor shape, attenuation of posterior echo, blurred boundary, micro calcification and burr sign in the breast cancer group were higher than those in the benign group (P＜0.05). The CA153, MUC1 and GDF3 levels in the breast cancer group were higher than those in the control group and benign group (P＜0.05), and the benign group was higher than the control group (P＜0.05). The positive rates of CA153, MUC1, GDF3 and color Doppler ultrasound and the 4 items combined tests in the breast cancer group were significantly higher than those in the benign group and control group (P＜0.05), but there were no significant differences between the positive rates of the benign group and control group in CA153, MUC1, GDF3 and the 4 items combined tests (P＞0.05). The positive rate of color Doppler ultrasound in the benign group was higher than that in the control group (P＜0.05). Among the 3 items serum markers the sensitivity, specificity and accuracy of CA153 were the highest of 52.38%, 89.73% and 76.21%, the sensitivity, specificity and accuracy of color Doppler ultrasound were 84.76%, 83.24% and 83.79%, respectively. the sensitivity and accuracy of the 4 items combined were the highest of 94.28%. 88.27%, the specificity was 84.86%. Conclusion CA153, MUC1 and GDF3 all present high levels in breast cancer patients. Color Doppler ultrasound combined with the above 3 indexes can improve the diagnostic effect of early breast cancer. |
