| Objective To investigate the relationship between serum osteopontin (OPN), vascular endothelial growth factor (VEGF), homocysteine (Hcy) and renal function and cognitive dysfunction (CD) in elderly patients with type 2 diabetic kidney disease (T2DKD). Methods 140 patients with T2DKD who were admitted to the Second Affiliated Hospital of Anhui Medical University from January 2017 to June 2022 were selected as T2DKD group. According to the occurrence of CD, they were divided into CD group with 41 cases and non-CD group with 99 cases, 60 patients with simple T2DM were selected as T2DM group, and 50 healthy volunteers during the same period were selected as control group. Serum OPN, VEGF, Hcy were measured and renal function indexes [urinary albumin/creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR)] were calculated. Spearman correlation was used to analyze the correlation between serum OPN, VEGF, Hcy levels and renal function indexes in elderly patients with T2DKD, and multivariate Logistic regression was used to analyze the influencing factors of CD in elderly patients with T2DKD. Results Serum OPN, VEGF, Hcy levels and UACR in the control group, T2DM group and T2DKD group were increased successively, while eGFR was decreased successively (P＜0.05). Spearman correlation analysis showed that serum OPN, VEGF and Hcy levels in elderly patients with T2DKD were positively correlated with UACR, and negatively correlated with eGFR (P＜0.05). Multivariate Logistic regression analysis showed that homeostasis model assessment-insulin resistance (HOMA-IR), OPN, VEGF and Hcy were elevated as independent risk factors for CD in elderly patients with T2DKD, and eGFR was elevated as an independent protective factor (P < 0.05). Conclusion Elevated serum OPN, VEGF and Hcy levels in elderly patients with T2DKD are closely related to renal function and CD, and which may be an auxiliary predictor of CD in elderly patients with T2DKD. |
