Objective: To investigate the effects of Sacubitril Valsartan sodium on renal function, neuroendocrine hormone and transforming growth factor-β1 (TGF-β1) /Smad3 signaling pathway in elderly patients with chronic heart failure (CHF) complicated with type 2 diabetes mellitus (T2DM). Methods: 92 elderly patients with CHF complicated with T2DM who were admitted to our hospital from May 2020 to May 2021 were selected, and they were divided into control group (n=46, receiving conventional treatment) and study group (n=46, receiving Sacubitril Valsartan sodium treatment on the basis of control group) according to dichromatic sphere method. Cardiac function, renal function, neuroendocrine hormone, TGF-β1/Smad3 signaling pathway related indicators and the occurrence of adverse reactions were compared in the two groups. Results: 12 months after treatment, the cardiac output (CO) and left ventricular ejection fraction (LVEF) in the study group were higher than those in the control group, and the left ventricular end-diastolic diameter (LVEDD) was lower than that in the control group (P<0.05). 12 months after treatment, serum creatinine (Scr), blood urea nitrogen (BUN), blood uric acid (UA), neutrophil?gelatinase-associated lipocalin (NGAL) and cystatin C (Cys-C) in the study group were lower than those in the control group (P<0.05). 12 months after treatment, norepinephrine (NE), aldosterone (ALD) and angiotensin II (AngII) in the study group were lower than those in the control group (P<0.05). 12 months after treatment, Smad7 mRNA in the study group was higher than that in the control group, while Smad2 mRNA, TGF-β1 mRNA and Smad3 mRNA were lower than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions in the two groups (P>0.05). Conclusion: Sacubitril Valsartan sodium is used to treat elderly patients with CHF complicated with T2DM, which can effectively improve the cardiac function, renal function, neuroendocrine hormone and TGF-β1/Smad3 signaling pathway related indicators, with a good safety. |