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| 通督调神针法联合穴位贴敷对老年气虚血瘀证缺血性脑卒中恢复期患者脑血流、血液流变学和血清NGF、BDNF的影响 |
| Effects of Tongdu Tiaoshen Acupuncture Combined With Acupoint Application on Cerebral Blood Flow, Hemorheology, Serum NGF and BDNF in Elderly Patients With Ischemic Stroke With Qi Deficiency and Blood Stasis Syndrome at Convalescent Stage |
| 投稿时间：2023-01-06 修订日期：2023-01-06 |
| DOI： |
| 中文关键词: 通督调神针法 穴位贴敷 老年 气虚血瘀证 缺血性脑卒中 恢复期 脑血流 血液流变学 NGF BDNF |
| 英文关键词: Tongdu Tiaoshen acupuncture Acupoint application Elderly Qi deficiency and blood stasis syndrome Ischemic stroke Convalescent stage Cerebral blood flow Hemorheology NGF BDNF |
| 基金项目:广东省中医药管理局项目（编号：201711102） |
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| 中文摘要: |
| 目的：探讨通督调神针法联合穴位贴敷对老年气虚血瘀证缺血性脑卒中恢复期患者脑血流、血液流变学和血清神经生长因子（NGF）、脑源性神经营养因子（BDNF）的影响。方法：本次研究纳入我院于2021年3月~2022年5月期间收治的70例老年气虚血瘀证缺血性脑卒中恢复期患者。采用信封抽签法分为对照组（n=35）和观察组（n=35）。对照组接受常规治疗，观察组在对照组的基础上接受通督调神针法联合穴位贴敷治疗。对比两组疗效、美国国立卫生研究院卒中量表（NIHSS）评分、中医证候积分、脑卒中专用生活质量量表（SS-QOL）评分、Fugl-Meyer运动功能量表（FMA）评分、脑血流指标、血液流变学指标和NGF、BDNF水平。结果：观察组的临床总有效率为94.29%（33/35），高于对照组的71.43%（25/35）（P<0.05）。观察组治疗4周后SS-QOL评分、FMA评分高于对照组同期，中医证候总积分、NIHSS评分低于对照组同期（P<0.05）。观察组治疗4周后血流阻力指数（RI）、搏动指数（PI）低于对照组同期，平均血流速度（Vm）高于对照组同期（P<0.05）。观察组治疗4周后全血低切黏度、血浆比黏度、全血高切黏度、纤维蛋白原均低于对照组同期（P<0.05）。观察组治疗4周后血清NGF、BDNF水平均高于对照组同期（P<0.05）。结论：通督调神针法联合穴位贴敷可有效改善老年气虚血瘀证缺血性脑卒中恢复期患者的脑血流、血液流变学，调节血清NGF、BDNF水平。 |
| 英文摘要: |
| Objective: To investigate the effects of Tongdu Tiaoshen acupuncture combined with acupoint application on cerebral blood flow, hemorheology, serum nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in elderly patients with ischemic stroke with Qi deficiency and blood stasis syndrome at convalescent stage. Methods: This study included 70 elderly patients with ischemic stroke with Qi deficiency and blood stasis syndrome at convalescent stage who were admitted to our hospital from March 2021 to May 2022. They were divided into the control group (n=35) and the observation group (n=35) by the envelope lottery method. The control group received conventional treatment, and the observation group received Tongdu Tiaoshen acupuncture combined with acupoint application based on the control group. The efficacy, the National Institutes of Health Stroke Scale (NIHSS) score, traditional Chinese medicine syndrome score, Stroke Special Quality of Life Scale (SS-QOL) score, Fugl-Meyer Motor Function Scale (FMA) score, cerebral blood flow indexes, hemorheology indexes, serum NGF and BDNF levels were compared in the two groups. Results: The total effective rate in the observation group was 94.29% (33/35), which was higher than 71.43% (25/35) in the control group (P<0.05). 4 weeks after treatment, the SS-QOL score and FMA score in the observation group were higher than those in the control group in the same period, while the total traditional Chinese medicine syndrome score and NIHSS score were lower than those in the control group in the same period (P<0.05). 4 weeks after treatment, the blood flow resistance index (RI) and pulse index (PI) in the observation group were lower than those in the control group in the same period, and the average blood flow velocity (Vm) was higher than that in the control group in the same period (P<0.05). 4 weeks after treatment, whole blood low shear viscosity, plasma specific viscosity, whole blood high shear viscosity and fibrinogen in the observation group were lower than those in the control group in the same period (P<0.05). 4 weeks after treatment, the levels of serum NGF and BDNF in the observation group were higher than those in the control group in the same period (P<0.05). Conclusion: Tongdu Tiaoshen acupuncture combined with acupoint application can effectively improve the cerebral blood flow and hemorheology of elderly patients with ischemic stroke of Qi deficiency and blood stasis syndrome at the convalescent stage, regulate the levels of serum NGF and BDNF. |
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