| Objective To investigate the correlation between serum complement C1q/tumor necrosis factor-related protein 4 (CTRP-4), CTRP-6 and CTRP-9 with lung function and inflammatory factors in elderly patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods 117 patients with AECOPD who were admitted to our hospital from January 2020 to January 2022 were selected as the AECOPD group, 72 patients with stable chronic obstructive pulmonary disease (SCOPD) were selected as the SCOPD group, and another 58 healthy people with physical examination during the same period were selected as the control group. Serum CTRP-4, CTRP-6 and CTRP-9 levels were measured by enzyme-linked immunosorbent assay, and the Pearson/Spearman correlation were used to analyze the correlation between serum CTRP-4, CTRP-6 and CTRP-9 and lung function indexes [forced expiratory volume in one second as a percentage of projected (FEV1%), forced expiratory volume in one second/forced vital capacity (FEV1/FVC)] and inflammatory factors [interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-α (TNF-α)] in elderly patients with AECOPD. Results The serum CTRP-4 level in the control group, SCOPD group and AECOPD group increased in turn, while the CTRP-6 and CTRP-9 levels decreased in turn (P＜0.05). Serum CTRP-4 level in elderly patients with AECOPD were negatively correlated with FEV1% and FEV1/FVC, and positively correlated with serum IL-1β, IL-6, IL-8, and TNF-α levels (P＜0.05). CTRP-6 and CTRP-9 levels were positively correlated with FEV1% and FEV1/FVC, and negatively correlated with serum IL-1β, IL-6, IL-8 and TNF-α levels (P＜0.05). Conclusion The increased serum CTRP-4 level and the decreased CTRP-6 and CTRP-9 levels are associated with the decreased lung function and inflammatory response in elderly patients with AECOPD, which may be a potential target for the prevention and treatment of AECOPD in the elderly. |
