| Objective: To investigate the relationship between serum Ferritin, cathepsin S (Cat S), monocyte chemotactic protein-1 (MCP-1) and insulin resistance in patients with gestational diabetes mellitus (GDM), and to analyze the influencing factors of pregnancy outcome in patients with GDM. Methods: A total of 154 parturients diagnosed with GDM in Shijiazhuang Maternal and Child Health Hospital from April 2019 to December 2021 were included as the GDM group, another 100 healthy parturients who came to Shijiazhuang Maternal and Child Health Hospital during the same period were taken as the control group. Serum Ferritin, Cat S, MCP-1 levels and homeostasis model insulin resistance index (HOMA-IR) were detected and compared between the two groups, and the correlation between serum Cat S, Ferritin, MCP-1 and HOMA-IR was analyzed by Pearson correlation coefficient. The GDM group was divided into normal pregnancy outcome group and poor pregnancy outcome group according to pregnancy outcome, and the influencing factors of pregnancy outcome were analyzed by multiple Logistic regression. Results: The serum Ferritin, Cat S, MCP-1 levels and HOMA-IR in GDM group were higher than those in control group (P<0.05). Pearson correlation analysis showed that serum Cat S, Ferritin and MCP-1 levels were positively correlated with HOMA-IR in patients with GDM (P<0.05). Among 154 patients with GDM, 58 cases had adverse pregnancy outcomes, accounting for 37.66%. Univariate analysis showed that pregnancy outcome of patients with GDM was related to diabetes family history, gestational age at diagnosis of GDM, age, oral glucose tolerance test (OGTT) results, pre-pregnancy body mass index (BMI), serum Ferritin, Cat S, MCP-1 levels and HOMA-IR (P<0.05). Multivariate Logistic regression analysis showed that age ≥35 years, pre-pregnancy BMI≥24kg/m2, OGTT results > 2 items abnormal, and serum Ferritin, Cat S and MCP-1 high levels were risk factors for poor pregnancy outcome in patients with GDM (P<0.05). Conclusion: The serum Ferritin, Cat S and MCP-1 levels in patients with GDM are abnormally elevated, which are related to insulin resistance. Pregnancy outcomes of patients with GDM are affected by Ferritin, Cat S, MCP-1 levels, age, pre-pregnancy BMI, OGTT results and other factors. |
