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| AVF与TCC血管通路在慢性肾衰竭患者中的血液透析效果比较及对炎性因子、营养水平和肾功能的影响 |
| Comparison of hemodialysis effects between AVF and TCC vascular pathway in patients with chronic renal failure and its effects on inflammatory factors, nutritional level and renal function |
| 投稿时间：2022-06-09 修订日期：2022-06-09 |
| DOI： |
| 中文关键词: 自体动静脉内瘘 带隧道带涤纶套透析导管 慢性肾衰竭 血液透析 炎性因子 营养 肾功能 |
| 英文关键词: Autologous arteriovenous fistula Tunnel cuffed catheter Chronic renal failure Hemodialysis Inflammatory factors Nutrition Renal function |
| 基金项目:安徽省科技计划项目（1708A26） |
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| 中文摘要: |
| 目的 探析自体动静脉内瘘（AVF）、带隧道带涤纶套透析导管（TCC）在慢性肾衰竭（CRF）患者中的血液透析效果比较及对炎性因子、营养水平和肾功能的影响。方法 将2019年1月-2021年1月在本院接受诊治的150例CRF患者纳入研讨，所有患者根据随机数字表法分为AVF组、TCC组两组，例数各为75例。观察两组血液透析效果并进行比较，对比两组炎性因子、营养水平和肾功能的变化情况，记录两组并发症发生情况。结果 AVF组透析6个月后尿素清除指数（KT/V）、尿素清除率（URR）高于TCC组（P<0.05）。AVF组透析6个月后白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-ɑ）、超敏C反应蛋白（hs-CRP）低于TCC组（P<0.05）。AVF组透析6个月后白蛋白（ALB）、前白蛋白（PAB）高于TCC组（P<0.05）。两组透析6个月后尿素氮（BUN）、肌酐（Scr）较治疗前下降，且AVF组低于TCC组（P<0.05）。AVF组的并发症发生率低于TCC组（P<0.05）。结论 CRF患者采取AVF通路行血液透析治疗，临床效果较采取TCC通路更为显著，可有效改善患者肾功能，降低血液炎性因子水平，同时还可以降低并发症发生率，对机体营养状况的影响相对轻微，具有较好的临床应用价值。 |
| 英文摘要: |
| Objective To compare the hemodialysis effects of autologous arteriovenous fistula (AVF) and tunnel cuffed catheter (TCC) in patients with chronic renal failure (CRF) and their effects on inflammatory factors, nutritional level and renal function. Methods 150 patients with CRF who were treated in our hospital from January 2019 to January 2021 were included in the study. All patients were randomly divided into AVF group and TCC group, with 75 cases in each group. The hemodialysis effects of the two groups were observed and compared, the changes of inflammatory factors, nutritional level and renal function were compared between the two groups, and the complications of the two groups were recorded. Results 6 months after dialysis, the urea clearance index (KT/V) and urea clearance rate (URR) in AVF group were higher than those in TCC group (P<0.05). In AVF group at 6 months after dialysis, interleukin-6 (IL-6), tumor necrosis factor (TNF- α) and high-sensitivity C-reactive protein (hs-CRP) were lower than those in TCC group (P<0.05). Albumin (ALB) and prealbumin (PAB) in AVF group at 6 months after dialysis were higher than those in TCC group (P<0.05). 6 months after dialysis, urea nitrogen (BUN) and creatinine (Scr) in the two groups decreased compared with those before treatment, and those in AVF group were lower than those in TCC group (P<0.05). The incidence of complications in AVF group was lower than that in TCC group (P<0.05). Conclusion The clinical effect of hemodialysis with AVF pathway in patients with CRF is more significant than that with TCC pathway. It can effectively improve the renal function of patients, reduce the level of blood inflammatory factors, and reduce the incidence of complications. It has a relatively slight impact on the nutritional status of the body, which has a better clinical application value. |
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