Objective: To investigate the effects of Shenshao tablets combined with metoprolol tartrate tablets on oxidative stress, vascular endothelial function and myocardial injury markers in patients with coronary heart disease and angina pectoris. Methods: Cases were selected from 110 patients with coronary heart disease and angina pectoris who were treated in our hospital from September 2018 to July 2021, According to the parity order of admission, the patients were divided into control group (55 cases) and observation group (55 cases). The patients in the control group were treated with metoprolol tartrate tablets, and the patients in the observation group were treated with Shenshao tablets combined with metoprolol tartrate tablets. The total clinical effective rate and ECG effective rate of the two groups were observed. The clinical symptoms and oxidative stress [superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-PX)], vascular endothelial function [endothelin (ET), vascular endothelial growth factor (VEGF), nitric oxide (NO)] and myocardial injury markers [cardiac troponin (cTn), creatine kinase isoenzyme (CK-MB), brain natriuretic peptide (BNP)] changes were compared between the two groups, the incidence of adverse reactions in the two groups was recorded. Results: Compared with the control group, the total clinical effective rate and ECG effective rate in the observation group were further increased (P<0.05). 12 weeks after treatment, the number of angina pectoris attacks in the observation group was less than that in the control group, the duration of angina pectoris was shorter than that in the control group, and the 6 min walking test distance was longer than that in the control group (P<0.05). 12 weeks after treatment, the levels of VEGF and ET in the observation group were lower than those in the control group, and the level of NO was higher than that in the control group (P<0.05). 12 weeks after treatment, the levels of CK-MB,cTn and BNP in the observation group were lower than those in the control group (P<0.05). 12 weeks after treatment, the level of MDA in the observation group was lower than that in the control group, and the levels of SOD and GSH-PX were higher than those in the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Shenshao tablet combined with metoprolol tartrate tablet in the treatment of patients with coronary heart disease and angina pectoris can promote the improvement of symptoms, reduce oxidative stress and vascular endothelial injury, and play a good myocardial protective effect. |