| Objective: To observe the protective effect of Ginkgolide injection combined with atorvastatin calcium tablet on nerve function in the treatment of acute cerebral infarction (ACI) and the effects on blood lipid, antioxidant capacity and toll-like receptor 4 (TLR4)/nuclear factor -κB (NF-κB) signaling pathway. Methods: A total of 152 patients with ACI who received treatment in Yongchuan Hospital Affiliated to Chongqing Medical University from June 2019 to June 2020 were selected and divided into two groups by random number table method: study group (n=76), who received Ginkgolide injection combined with atorvastatin calcium tablet. The control group (n=76) received atorvastatin calcium tablet. Both groups were treated for 14 days. The efficacy, nerve function, blood lipid, antioxidant capacity and TLR4/NF-κB signaling pathway changes were compared between the two groups, and the safety of medication was observed. Results: The total clinical effective rate of the study group was significantly higher than that of the control group (P<0.05). After treatment, national Institutes of Health neurological deficit score (NIHSS), neuron specific enolase (NSE) and S100β protein decreased in both groups, and the study group was lower than the control group (P<0.05). After treatment, total cholesterol (TC), low density lipoprotein (LDL-C) and triglyceride (TG) in both groups decreased, and the study group was lower than the control group (P<0.05), while high density lipoprotein (HDL-C) in both groups increased, and the study group was higher than the control group (P<0.05). After treatment, catalase (CAT), superoxide dismutase (SOD) and total antioxidant capacity (TAC) in both groups increased, and the study group was higher than the control group (P<0.05). After treatment, the levels of TLR4 and NF-κB in both groups decreased, and the study group was lower than the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Ginkgolide injection combined with atorvastatin calcium tablets in the treatment of ACI is beneficial to reduce nerve function injury, regulate blood lipid and improve antioxidant capacity, which may be related to the regulation of TLR4 / NF- κ B signal pathway. |
