文章摘要
通元针法对IVF-ET反复种植失败患者妊娠结局、性激素和焦虑抑郁影响的前瞻性随机对照研究
A prospective randomized controlled study on the effects of Tongyuan acupuncture on pregnancy outcome, sex hormone, anxiety and depression in patients with IVF-ET of repeated implantation failure
投稿时间:2022-04-06  修订日期:2022-04-06
DOI:
中文关键词: 通元针法  体外受精-胚胎移植  反复种植失败  妊娠结局  性激素  焦虑抑郁
英文关键词: Tongyuan acupuncture  In vitro fertilization embryo transfer  Repeated implantation failure  Pregnancy outcome  Sex hormones  Anxiety and depression
基金项目:广东省“登峰计划”高水平医院建设资助项目(211010010716)
作者单位邮编
金萍 广州中医药大学第一临床医学院 1510006
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中文摘要:
      目的:观察通元针法对体外受精-胚胎移植(IVF-ET)反复种植失败(RIF)患者妊娠结局、性激素和焦虑抑郁影响。方法:采用随机数字表法将广州中医药大学第一附属医院2019年5月到2021年4月期间收治的IVF-ET RIF患者122例分为对照组(61例,常规治疗)和研究组(61例,对照组的基础上接受通元针法治疗)。观察两组临床妊娠率、胚胎种植率,记录治疗期间不良反应发生情况,观察治疗前后子宫内膜厚度和子宫内膜血流参数、性激素和焦虑抑郁的变化情况。结果:研究组的临床妊娠率、胚胎种植率高于对照组(P<0.05)。治疗后,研究组孕酮、雌二醇水平高于对照组(P<0.05)。治疗后,研究组的子宫内膜血流搏动指数(PI)、子宫内膜血流阻力指数(RI)、子宫内膜血流收缩期最高血流速度/舒张末期血流速度(S/D)较治疗前降低,且低于对照组,子宫内膜厚度较对照组更厚(P<0.05)。治疗后,研究组Zung焦虑自评量表(SAS)、Zung抑郁自评量表(SDS)评分低于对照组(P<0.05)。两组不良反应发生率组间对比,无统计学差异(P>0.05)。结论:通元针法用于IVF-ET RIF患者,可有效调节人体性激素,缓解焦虑抑郁心情,改善妊娠结局,安全可靠。
英文摘要:
      Objective: To observe the effects of Tongyuan acupuncture on pregnancy outcome, sex hormone, anxiety and depression in patients with in vitro fertilization embryo transfer (IVF-ET) of repeated implantation failure (RIF). Methods: Using random number table method 122 patients with RIF who were treated in the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from May 2019 to April 2021 were divided into control group (61 cases, routine treatment) and study group (61 cases, treated with Tongyuan acupuncture on the basis of control group). The clinical pregnancy rate and embryo implantation rate of the two groups were observed, the adverse reactions during the treatment were recorded, and the changes of endometrial thickness, endometrial blood flow parameters, sex hormones, anxiety and depression were observed before and after treatment. Results: The clinical pregnancy rate and embryo implantation rate in the study group were higher than those in the control group (P<0.05). After treatment, the levels of progesterone and estradiol in the study group were higher than those in the control group (P<0.05). After treatment, the endometrial blood flow pulsatility index (PI), endometrial blood flow resistance index (RI) and endometrial blood flow the highest systolic blood flow velocity / end diastolic blood flow velocity (S/D) in the study group were lower than those before treatment, and lower than those in the control group, and the endometrial thickness was thicker than that in the control group (P<0.05). After treatment, the scores of Zung self rating Anxiety Scale (SAS) and Zung self rating Depression Scale (SDS) in the study group were lower than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Tongyuan acupuncture for patients with RIF of IVF-ET can effectively regulate human sex hormones, alleviate depression and anxiety, improve pregnancy outcome, and which is safe and reliable.
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