文章摘要
益生菌肠道准备联合早期肠内营养对腹腔镜直肠癌根治术患者营养状态、免疫功能和肠道菌群的影响
Effects of Probiotic Intestinal Preparation Combined With Early Enteral Nutrition on Nutritional Status, Immune Function and Intestinal Flora in Patients Undergoing Laparoscopic Radical Resection of Rectal Cancer
投稿时间:2022-04-06  修订日期:2022-04-06
DOI:
中文关键词: 益生菌肠道准备  早期肠内营养  腹腔镜直肠癌根治术  营养状态  免疫功能  肠道菌群
英文关键词: Probiotic intestinal preparation  Early enteral nutrition  Laparoscopic radical resection of rectal cancer  Nutritional status  Immune function  Intestinal flora
基金项目:陕西省重点研发项目(2017ZDXM-SF-053)
作者单位邮编
孙豪 空军军医大学第一附属医院 710032
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中文摘要:
      目的:观察益生菌肠道准备联合早期肠内营养对腹腔镜直肠癌根治术患者营养状态、免疫功能和肠道菌群的影响。方法:选择2020年1月-2020年12月期间我院收治的86例腹腔镜直肠癌根治术患者,根据随机数字表法分为对照组和研究组,各为43例。对照组患者接受传统肠道准备和术后处理,研究组患者接受益生菌肠道准备联合早期肠内营养,对比两组围术期指标、营养状态、免疫功能和肠道菌群和并发症发生率。结果:两组首次排气时间、留置导尿管时间组间对比无统计学差异(P>0.05)。研究组术中出血量、住院费用少于对照组,术后住院时间短于对照组(P<0.05)。研究组术后7d总蛋白(TP)、前清蛋白(PA)、清蛋白(ALB)、转铁蛋白(TF)水平较术前升高,且高于对照组(P<0.05)。研究组术后7d CD3+、CD4+、CD4+/CD8+高于对照组,CD8+低于对照组(P<0.05)。两组术后7d双歧杆菌、乳杆菌、大肠埃希菌数量均下降,但研究组高于对照组(P<0.05)。研究组的并发症发生率4.66%(2/43)低于对照组18.60%(8/43)(P<0.05)。结论:益生菌肠道准备联合早期肠内营养用于腹腔镜直肠癌根治术患者,有利于改善患者的营养状态,减轻免疫抑制,减轻对肠道菌群的影响,同时还可减少并发症的发生率。
英文摘要:
      Objective: To observe the effects of probiotic intestinal preparation combined with early enteral nutrition on nutritional status, immune function and intestinal flora in patients undergoing laparoscopic radical resection of rectal cancer. Methods: 86 patients with laparoscopic radical resection of rectal cancer who were treated in our hospital from January 2020 to December 2020 were selected, and they were randomly divided into control group and study group by random number table method, with 43 cases in each group. The patients in the control group received traditional intestinal preparation and postoperative treatment, and the patients in the study group received probiotic intestinal preparation combined with early enteral nutrition. The perioperative indexes, nutritional status, immune function, intestinal flora and the incidence of complications were compared between the two groups. Results: There were no significant differences in the first exhaust time and indwelling catheter time between the two groups (P>0.05). The amount of intraoperative bleeding and hospitalization expenses in the study group were less than those in the control group, and the postoperative hospitalization time was shorter than that in the control group (P<0.05). The levels of total protein (TP), prealbumin (PA), albumin (ALB) and transferrin (TF) in the study group at 7d after operation increased than those before operation, and the study group was higher the control group (P<0.05). CD3+, CD4+, CD4+/ CD8+ in the study group at 7d after operation were higher than those in the control group, and CD8+ was lower than that in the control group (P<0.05). Bifidobacteria, Lactobacillus and Escherichia coli in the two groups at 7d after operation decreased, but the study group was higher than the control group (P<0.05). The complication rate of study group was 4.66% (2/43) lower than 18.60% (8/43) of control group (P<0.05). Conclusion: Probiotic intestinal preparation combined with early enteral nutrition in patients undergoing laparoscopic radical resection of rectal cancer can improve the nutritional status of patients, reduce immunosuppression, reduce the impact on intestinal flora, and reduce the incidence of complications.
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