| Objective:To observe the clinical efficacy of periodontal basic treatment and periodontal regeneration combined with orthodontic treatment in patients with extensive invasive periodontitis complicated with alveolar bone defect and the effects on serum inflammatory factors and gingival sulcus bacterial microecology.Methods:The clinical data of 83 patients with generalized aggressive periodontitis with alveolar bone defect who were received in our hospital from August 2017 to August 2018 were analyzed. According to the different treatment methods, the patients were divided into group A (40 cases, periodontal basic treatment and periodontal regeneration)and group B (43 cases, periodontal basic treatment and periodontal regeneration combined with orthodontic treatment) . The therapeutic effect, serum inflammatory factors, microbial ecology of gingival groove bacteria, periodontal index, alveolar bone mineral density and alveolar defect height were observed in the two groups. Results:The total clinical effective rate of group B was higher than that of group A (P<0.05). The gingival sulcus bleeding index (SBI), periodontal depth (PD), clinical attachment loss (AL), plaque index (PLI) and gingival index (GI) of group B after treatment were lower than those of group A (P<0.05). The height of alveolar defect of group B was lower than that of group A, and the alveolar bone mineral density was higher than that of group A (P<0.05). After treatment, the serum levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) of group B were lower than those of group A (P<0.05). The detection rate of?bacillus, cocci, filamentous bacteria and campylobacter of group B after treatment were lower than those of group A, and detection rate of spindle bacteria and spirochete were higher than those of group A (P<0.05). Conclusion: Periodontal basic treatment and periodontal regeneration combined with orthodontic treatment for extensive invasive periodontitis combined with alveolar bone defect have significant effect, which can effectively improve the periodontal condition and reduce the level of inflammatory factors, but the combined treatment can destroy the oral bacterial microecology. Therefore, when receiving orthodontic treatment, attention should be paid to oral cleanliness to minimize the impact on the bacterial microecology of gingival crevise. |
