| Objective To observe the effect of Kuntai capsule combined with fenmatong on sex hormone, immune function and quality of life in patients with perimenopausal syndrome. Methods A total of 90 patients with perimenopausal syndrome who were admitted to our hospital from March 2017 to March 2020 were included. Random number table method was used to divide them into two groups: study group and control group, with 45 cases each, who received Kuntai capsule combined with fenmatong treatment and fenmatong treatment respectively, and the curative effect, sex hormone, immune function, quality of life and adverse reactions of the two groups were observed. Results Compared with the control group, the clinical total effective rate of the study group was significantly higher (P<0.05). 3 courses after treatment, estradiol (E2) in group A increased, and the study group was higher than the control group. The follicle-forming hormone (FSH) and luteinizing hormone (LH) of the study group were decreased, and the study group was lower than the control group (P<0.05). 3 courses after treatment, CD3+, CD4+, CD4+/ CD8+ of the two groups were increased, and the study group was higher than the control group. CD8+ decreased, and the study group was lower than the control group (P<0.05). 3 courses after treatment, the scores of each dimension and total score of menopause-specific quality of life questionnaire (MENQOL) in the two groups decreased, and the study group was lower than the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Kuntai capsule combined with fenmatong can effectively regulate the level of sex hormones in patients with perimenopausal syndrome, improve the immune function and quality of life of patients, which is a relatively safe and effective treatment plan. |
