| Objective: To observe the clinical efficacy of Shugan Jianpi acupuncture in the treatment of diarrhea irritable bowel syndrome (IBS-D) with liver depression and spleen deficiency syndrome and its effects on intestinal flora, serum serotonin (5-HT), calcitonin gene-related peptide (CGRP) and neuropeptide Y (NPY). Methods: 96 IBS-D patients with liver depression and spleen deficiency syndrome were all outpatients or inpatients who were treated in Tianjin People''s Hospital from May 2018 to February 2021 were selected. According to the two-color ball method, the patients were divided into control group and study group, with 48 cases in each group. The control group was treated with western medicine. The study group was treated with Shugan Jianpi acupuncture on the basis of the control group. The curative effect, TCM syndrome score, intestinal flora and the changes of serum 5-HT, NPY and CGRP were compared between the two groups. Results: The total clinical effective rate of the study group was significantly higher than that of the control group (P < 0.05). After the course of treatment, the symptom scores of loose stool, less abdominal pain, abdominal distension after eating, anorexia, mental fatigue, bitter mouth and sticky mouth, limb weakness, irritability and irritability, fear of cold and fear of cold in the study group were lower than those in the control group (P < 0.05). After the course of treatment, the levels of serum 5-HT, NPY and CGRP in the study group were lower than those in the control group (P < 0.05). After treatment, the number of bifidobacteria, bifidobacteria / Escherichia coli ratio and Lactobacillus in the study group were higher than those in the control group, while the number of Escherichia coli was lower than that in the control group (P < 0.05). Conclusion: Shugan Jianpi acupuncture in the treatment of IBS-D patients with liver depression and spleen deficiency can effectively promote the improvement of symptoms, regulate intestinal flora and reduce the levels of serum 5-HT, NPY and CGRP. |
