Objective: To investigate the effects of different orthodontic treatments on the tooth movement distance and the levels of tumor necrosis factor-α(TNF-α), interleukin-2 (IL-2), hepatocyte growth factor (HGF) and pentraxins 3 (PTX3) in gingival crevicular fluid. Methods: 288 patients with malocclusion (malocclusion) who were admitted to our hospital from July 2016 to December 2019 were selected, and they were divided into four groups by random number table method, with 72 cases in each group. All patients were treated with square wire appliance, and were given distal orthodontic forces of 50g (group A), 100g (group B), 150g (group C) and 250g (group D), respectively. The tooth movement distance of the four groups was observed 1d, 3d, 1 week, 2 weeks, 3 weeks and 4 weeks after orthodontic treatment, as well as the changes of the levels of TNF-α, IL-2, HGF and PTX3 in gingival crevicular fluid and differences between groups at before orthodontic, 1 week, 2 weeks, 3 weeks and 4 weeks after orthodontic treatment. Results: The tooth displacement distance of the four groups was first extended and then shortened after orthodontic treatment for 1 day, 3 days, 1 week, 2 weeks, 3 weeks and 4 weeks, and then it was extended again and gradually returned to the baseline level (P<0.05). The TNF-α, IL-2, HGF and PTX3 of the four groups were increased first and then decreased after orthodontic treatment for 1 day, 3 days, 1 week, 2 weeks, 3 weeks and 4 weeks, and then gradually gone up again returned to the baseline level (P<0.05). There were interaction effects between tooth displacement distance, TNF-α, IL-2, HGF and PTX3 and time (P<0.05). The displacement distance of group B at 1d, 3d, 1 week, 2 weeks, 3 weeks and 4 weeks after orthodontic treatment were greater than that of group A (P<0.05). and there were no statistical differences between group C, group D and group A (P>0.05). The levels of TNF-α, IL-2, HGF and PTX3 in gingival crevicular fluid of group D at 1d, 3d, 1 week, 2 weeks, 3 weeks and 4 weeks after orthodontic treatment were all higher than those of group A, group B and group C (P<0.05), while those of group C were higher than those of group A and group B (P<0.05), there was no significant difference between group A and group B (P>0.05). Conclusion: 100g orthodontic force can promote the tooth movement, maintain the appropriate level of cytokines during orthodontic treatment, reduce the damage to periodontal tissue, which is conducive to the recovery of periodontal tissue. |