Objective: To investigate the effects of dexmedetomidine combined with dezocine on cognitive function, oxidative stress and inflammatory factors in elderly patients after laparoscopic cholecystectomy. Methods: 103 elderly patients who were planned to undergo laparoscopic cholecystectomy and admitted in our hospital from April 2017 to December 2019 were prospectively selected, patients were divided into group A, B by random number table method. 51 cases in group A, given sufentanil for analgesia, 52 cases in group B, given dexmedetomidine combined with dezocine intravenous analgesia. The adverse reactions, sedation, analgesic effect, cognitive function, oxidative stress and inflammatory factors were compared between the two groups. Results: The visual analogue scale(VAS)scores of group B were lower than those of group A at 12h, 24h, 48h after operation (P < 0.05), Ramsay sedation scores of group B were higher than those of group A at 12h, 24h and 48h after operation (P < 0.05). The scores of mini-mental state examination(MMSE)at 1d after operation, 3d after operation, 5d after operation in group B were higher than those of group A (P < 0.05), the incidence of postoperative cognitive dysfunction (POCD) in group B was lower than that of group A (P < 0.05). Malondialdehyde (MDA) at 3d after operation, 5d after operation in group B were lower than those of group A, the total antioxidant capacity (T-AOC), superoxide dismutase (SOD) in group B were higher than those of group A (P < 0.05). The levels of interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs CRP), tumor necrosis factor - α (TNF - α) at 3d after operation, 5d after operation in group B were lower than those of group A (P < 0.05). There was no difference in adverse reactions between the two groups (P > 0.05). Conclusion: Compared with sufentanil, on the basis of dezocine intravenous analgesia, combined with dexmedetomidine, can obtain better analgesic and sedative effect in elderly patients with laparoscopic cholecystectomy, which can reduce cognitive impairment, oxidative stress and inflammatory reaction, and is safe and reliable. |