| Objective: To investigate the changes of tidal breathing pulmonary function and D-dimer level in infants with severe pneumonia and the study of intervention effect of ambroxol hydrochloride. Methods: 122 infants with severe pneumonia admitted to our hospital from January 2016 to December 2019 were selected as the pneumonia group, and 100 infants who came to our hospital for health examination at the same period were selected as the control group. The pneumonia group was randomly divided into group A (n = 61, conventional treatment) and group B (n = 61, combined with ambroxol hydrochloride on the basis of conventional treatment) by random number table method, and the tidal breathing, pulmonary function and D-dimer level of control group and pneumonia group was compared. The curative effect, tidal breathing pulmonary function, D-dimer, symptom remission time and adverse reactions of group A and group B were compared. Results: The respiratory rate (RR) and D-dimer levels in the pneumonia group were higher than those in the control group, while the tidal volume (VT), time to peak (TPTEF), inspiratory time (TI) and expiratory time (TE) in the pneumonia group were lower than those in the control group (P < 0.05). The total effective rate in group B was higher than that in control group at 1 week after treatment (P < 0.05). 1 week after treatment, RR and D-dimer in both groups were decreased, and group B was lower than the control group (P < 0.05). 1 week after treatment, VT, TPTEF, TI, TE in both groups were increased, and group B was higher than group A (P < 0.05). The antipyretic time, cough relief time, shortness of breath remission time and rales disappearance time in group B were shorter than those in group A (P < 0.05). There was no difference in the total incidence of adverse reactions between group A and group B (P > 0.05). Conclusion: The detection of D-dimer and tidal breathing pulmonary function can be used as an important index to evaluate the severity and treatment effect of severe pneumonia in infants. After ambroxol hydrochloride intervention, tidal breathing pulmonary function and D-dimer can be significantly improved, clinical symptoms can be effectively alleviated, the curative effect is affirmative, and there is no increase in adverse reactions. |
