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| 肺癌根治术后并发症危险因素分析及其生活质量变化研究 |
| Analysis of risk factors of complications after radical operation of lung cancer and study on changes of life qualityCHEN Yi-jie, FEI Yi*, CHEN Xian-shan, CHEN Min-biao, WU Duo-zhi |
| 投稿时间：2021-01-05 修订日期：2021-01-05 |
| DOI： |
| 中文关键词: 肺癌根治术 并发症 危险因素 生活质量 |
| 英文关键词: Radical resection of lung cancer Complications Risk factors Quality of life |
| 基金项目:海南省自然科学基金项目(309063) |
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| 中文摘要: |
| 目的 探讨肺癌根治术后并发症的危险因素,并分析其生活质量的变化。方法 纳入我院2018年9月～2020年7月收治的行肺癌根治术患者104例,对患者的临床资料进行回顾性分析。根据患者术后3个月的并发症发生情况,分成并发症组(n=32)和非并发症组(n=72),分析肺癌根治术后并发症发生的影响因素,利用癌症病人生活质量测定量表(QLQ-C30)评估患者术前及术后3个月的生活质量。结果 肺癌根治术后32例出现并发症,其中切口感染6例,肺炎7例,肺不张9例,心律失常6例,脓胸4例。并发症组年龄≥60岁、烟龄≥10年、传统开胸术、慢性阻塞性肺疾病史人数占比高于非并发症组(P＜0.05)。多因素Logistic回归分析显示,年龄≥60岁(OR=2.978,95%CI：1.415-6.267)、烟龄≥10年(OR=3.847,95%CI：1.869-7.918)、传统开胸术(OR=3.065,95%CI：1.544-6.084)、慢性阻塞性肺疾病史(OR=2.848,95%CI：1.481-5.477)是肺癌根治术后患者发生并发症的危险因素(P＜0.05)。非并发症组术后3个月的总体生活质量量表、角色功能、躯体功能、情绪功能、社会功能评分高于术前与并发症组,且恶心呕吐、疲乏、疼痛、便秘、呼吸困难、食欲下降、睡眠障碍、腹泻评分较术前与并发症组明显降低(P＜0.05)。结论 肺癌根治术后并发症的发生主要与患者年龄、烟龄、手术方式、慢性阻塞性肺疾病史有关,且并发症对患者术后生活质量影响较大。 |
| 英文摘要: |
| Objective To explore the risk factors of complications after radical resection of lung cancer, and to analyze the changes in the quality of life. Methods A total of 104 patients undergoing radical resection of lung cancer who were admitted to our hospital from September 2018 to July 2020 were included. The clinical data of the patients were retrospectively analyzed. The patients were divided into complication group (n=32) and non-complication group (n=72) according to their complications 3 months after operation, the influencing factors postoperative complications of radical resection of lung cancer were analyzed, and the quality of life of patients before and 3 months after operation was evaluated using the Quality of life measurement scale for cancer patients (QLQ-C30). Results In 32 cases of complications after radical resection of lung cancer, there were 6 cases of incision infection, 7 cases of pneumonia, 9 cases of atelectasis, 6 cases of arrhythmia and 4 cases of empyema. The proportion of age ≥ 60 years, smoking age ≥ 10 years, traditional thoracotomy and chronic obstructive pulmonary disease history in the complication group were higher than those in the non-complication group (P < 0.05). Multivariate Logistic retrospective analysis showed that age ≥ 60 years (OR=2.978, 95%CI: 1.415-6.267), smoking age ≥ 10 years (OR=3.847, 95%CI: 1.869-7.918), traditional thoracotomy (OR=3.065, 95%CI: 1.544-6.084), chronic obstructive pulmonary disease history (OR=2.848, 95%CI: 1.481-5.477) were risk factors for complications (P<0.05). The scores of general quality of life scale, role function, physical function, emotional function and social function in the non-complication group were higher than those in the preoperative and complication group, and the scores of nausea and vomiting, fatigue, pain, constipation, dyspnea, loss of appetite, sleep disorder and diarrhea were significantly lower than those in the preoperative and complication group (P<0.05). Conclusion The incidence of complications after radical resection of lung cancer is mainly related to the patient''s age, smoking age, operation mode and chronic obstructive pulmonary disease history, and the complications have a great impact on the quality of life of patients after operation. |
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