| Objective: To investigate the relationship between serum soluble vascular cell adhesion molecule-1 (sVCAM-1), growth differentiation factor-15 (GDF-15), α-klotho protein, chitinase 3-like protein 1 (YKL-40) and glucose and lipid metabolism, insulin resistance and renal function in patients with type 2 diabetic (T2DM) nephropathy. Methods: 80 patients with T2DM in our hospital from February 2017 to May 2020 were selected, they were divided into T2DM without nephropathy group (n = 43) and T2DM nephropathy group (n = 37) according to the presence or absence of diabetic nephropathy. 50 healthy volunteers in our hospital during the same period were selected as the control group. Blood lipid indexes: total cholesterol (TC), high density lipoprotein (HDL), triglyceride (TG), low density lipoprotein (LDL), renal function indexes: urea nitrogen (BUN), creatinine (SCR), blood glucose indexes: glycosylated hemoglobin (HbA1c), fasting blood glucose (FPG), insulin resistance indexes: homeostasis model insulin resistance index (HOMA-IR), GDF-15, sVCAM-1, α-klotho protein, YKL-40 levels were detected. The correlation of serum GDF-15, sVCAM-1, YKL-40, α-klotho protein levels with blood glucose, blood lipid, insulin resistance and renal function were analyzed. Results: The levels of serum α-klotho protein in T2DM without nephropathy group and T2DM nephropathy group were lower than those in control group, and the T2DM nephropathy group was lower than that in T2DM without nephropathy group (P < 0.05). The serum levels of sVCAM-1, GDF-15 and YKL-40 in T2DM without nephropathy group and T2DM nephropathy group were higher than those in control group, and the T2DM nephropathy group was higher than that in T2DM without nephropathy group (P < 0.05). The levels of TC, TG, LDL, BUN, HOMA-IR, Scr, FPG and HbA1c in T2DM nephropathy group and T2DM without nephropathy group were higher than those in control group, and the T2DM nephropathy group was higher than that in T2DM without nephropathy group (P < 0.05). The levels of HDL in T2DM nephropathy group and T2DM without nephropathy group were lower than those in control group, and the T2DM nephropathy group was lower than that in T2DM without nephropathy group (P < 0.05). Pearson correlation analysis showed that GDF-15, sVCAM-1 and YKL-40 were positively correlated with TC, TG, LDL, BUN, Scr, FPG, HbA1c and HOMA-IR, but negatively correlated with HDL (P < 0.05). α - Klotho protein was negatively correlated with TC, TG, LDL, BUN, Scr, FPG, HbA1c and HOMA-IR, but positively correlated with HDL (P < 0.05). Conclusion: The abnormal expression of GDF-15, sVCAM-1, YKL-40 and α-klotho proteins in the serum of patients with T2DM nephropathy may be involved in the occurrence and development of the disease. |
