Objective: To observe the effect of isosorbide mononitrate combined with Dengzhan Shengmai Capsule on blood lipid, cardiac function and serum C-reactive protein (CRP) and interleukin-6 (IL-6) levels in elderly patients with coronary heart disease and angina pectoris. Methods: 92 elderly patients with coronary heart disease and angina pectoris in our hospital from March 2018 to July 2020 were selected, and they were divided into two groups by drawing lots, 46 cases in the control group and 46 cases in the study group. The control group was treated with isosorbide mononitrate, while the study group was treated with Dengzhan Shengmai capsule combined with isosorbide mononitrate. The course of treatment was 3 months. The clinical symptoms, electrocardiographic effect, cardiac function, blood lipid, serum IL-6 and CRP levels were compared between the two groups, and the incidence of adverse reactions was recorded. Results: The total effective rate of the study group was higher than that of the control group (P < 0.05). The total effective rate of electrocardiographic in the study group was higher than that in the control group (P < 0.05). After 3 months of treatment, the levels of serum low density lipoprotein cholesterol (LDL-C), triglyceride (TG), total cholesterol (TC), IL-6 and CRP in the two groups were lower than those before treatment, and the level of high density lipoprotein cholesterol (HDL-C) in the study group was higher than that in the control group (P < 0.05). After 3 months of treatment, the left ventricular end systolic diameter (LVESD) of the two groups was lower than that before treatment, and the study group was lower than that of the control group (P < 0.05), the left ventricular ejection fraction (LVEF) and cardiac output (CO) were higher than those before treatment, and the study group was higher than that of the control group (P < 0.05). There was no difference in the incidence of adverse reactions between the two groups (P > 0.05). After 3 months of treatment, the dosage of nitroglycerin in the study group was less than that in the control group, the frequency of angina pectoris attack, the duration of angina pectoris and the remission time of angina pectoris in the study group were shorter than those in the control group (P < 0.05). Conclusion: The combination of isosorbide mononitrate sustained-release tablets and Dengzhan Shengmai capsule in the treatment of elderly patients with coronary heart disease and angina pectoris has significant effect, which can effectively improve their cardiac function, blood lipid, regulate the level of inflammatory factors, and has good safety. |