文章摘要
滋养细胞胞内双链DNA感受器通过MAPK/IκB信号介导炎性细胞因子分泌<sub><sup>*</sup></sub>
Trophoblastic intracellular double-stranded DNA sensors mediate inflammatory cytokines secretion via MAPK/ IκB signaling pathway
投稿时间:2019-11-06  修订日期:2019-11-06
DOI:
中文关键词: 
英文关键词: Intracellular double-stranded DNA sensor  Trophoblast cells  MAPK/IκB signaling pathway  Inflammatory cytokines  
基金项目:广东省自然科学基金(2017A030310646,2019A1515011068);广东省科技计划项目(2016A020215207);深圳市科技计划项目(JCYJ20180228164515747);中国博士后基金(2018M643371)。
作者单位E-mail
张慧   
任莉莉   
高宇 深圳市人民医院  
李宁 深圳市人民医院 lining.yatu@hotmail.com 
摘要点击次数: 226
全文下载次数: 0
中文摘要:
      目的:探究滋养细胞能否感受胞内双链DNA刺激及其对炎性因子分泌的影响,揭示胎盘的免疫识别和免疫屏障功能,探讨妊娠期感染所致不良妊娠结局的发病机制。
英文摘要:
      Objective: The study was preformed to investigate the expression pattern of intracellular double-stranded DNA sensors in human trophoblast cells and its effect on the secretion of inflammatory factors, to reveal the immune recognition and immune barrier function of placenta, and to better understand the pathogenesis of adverse pregnancy outcomes caused by pregnancy infection.
View Fulltext   查看/发表评论  下载PDF阅读器
关闭