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| CDX2和HNF4α在胃癌中的相关表达及其临床意义 |
| Correlation and clinical significance of CDX2 and HNF4α in gastric cancer |
| 投稿时间：2018-12-07 修订日期：2018-12-13 |
| DOI： |
| 中文关键词: CDX2 HNF4α 肠化生 胃癌 |
| 英文关键词: CDX2 HNF4α Intestinal metaplasia Gastric cancer |
| 基金项目:国家自然科学基金项目(81470805，81873554) |
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| 中文摘要: |
| 目的：探讨尾侧型同源转录因子2 (Caudal type homeobox transcription factor-2, CDX2) 和肝细胞核因子4α (Hepatocyte nuclear factor 4α, HNF4α)在胃癌组织中的表达，并分析其与胃癌临床病理特征和预后的关系。方法：采用免疫组化染色法检测53例慢性胃炎、86例肠化生、97例胃癌患者组织标本中CDX2、P1-HNF4α和P2-HNF4α的表达，分析它们在胃癌组织中表达的相关关系，并结合胃癌患者9年随访资料分析CDX2和HNF4α对胃癌患者预后的评估意义。结果：CDX2蛋白在肠化生组中的表达水平显著高于慢性胃炎组和胃癌组(P＜0.05)。CDX2蛋白在胃癌中的表达与性别、淋巴结是否转移和TNM分期有关。P1-HNF4α在胃癌组中的表达明显高于慢性胃炎组，在肠化生组显著高于胃癌组(P＜0.01)。P1-HNF4α在胃癌中的表达与T分期相关。P2-HNF4α在慢性胃炎组中的表达显著低于肠化生组和胃癌组(P＜0.01)，而肠化生组与胃癌组之间比较差异无统计学意义。P2-HNF4α在胃癌中的表达与临床TNM分期相关。胃癌患者中P2-HNF4α高表达与预后不良相关。胃癌组织中CDX2、P1-HNF4α及P2-HNF4α的表达间均存在显著正相关(P＜0.01)。结论：CDX2和HNF4α在胃癌组织中均存在不同程度的表达，且三者之间存在显著相关性，它们可能共同参与了胃癌的发生发展。 |
| 英文摘要: |
| Objective：To investigate the expression of caudal homologous transcription factor 2 (CDX2) and hepatocyte nuclear factor 4α (HNF4α) in gastric cancer(GC) tissues, and to analyze their relationship with the clinicopathological characteristics as well as patients prognosis. Methods：The expression of CDX2、P1-HNF4α and P2-HNF4α in 53 cases of chronic gastritis, 86 cases of intestinal metaplasia and 97 cases of gastric cancer tissues were detected by immunohistochemical staining, and their correlation in gastric cancer tissues was analyzed. The relationship between CDX2 and HNF4α and the prognosis of patients with gastric cancer were further analyzed with the 9-year follow-up data. Results：The expression level of CDX2 protein was highest in intestinal metaplasia comparing to chronic gastritis and gastric cancer. The expression of CDX2 protein in GC correlates to sex, lymphatic metastasis and TNM stage. The expression level of P1-HNF4α in intestinal metaplasia was significantly higher than that both in chronic gastritis and in GC(P＜0.05). The expression of P1-HNF4α in GC was correlated to T stage only. The expression of P2-HNF4α in chronic gastritis was significantly lower than that in intestinal metaplasia and GC(P<0.01), there was no significant difference of P2-HNF4α between intestinal metaplasia and GC. The expression of P2-HNF4α in GC was correlated to TNM stage and poor prognosis. There was a significant correlation between CDX2 and P1-HNF4α as well as P2-HNF4α in gastric cancer(P<0.01). Conclusions: Both CDX2 and HNF4α are expressed at different degrees in gastric cancer tissues. They may have a role in development of gastric cancer. |
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