|
| 脂溶性维生素A、D、E与妊娠期糖尿病相关性分析 |
| Correlation analysis between fat-soluble vitamins A, D and E and gestational diabetes |
| 投稿时间：2018-10-18 修订日期：2018-10-18 |
| DOI： |
| 中文关键词: 妊娠期糖尿病 维生素A 25-羟基维生素D 维生素E |
| 英文关键词: Gestational diabetes mellitus,vitamin A,25-hydroxyvitamin D,vitamin E |
| 基金项目:国家卫生计生委医药卫生科技发展研究中心（课题编号：W2015CAE127） |
|
| 摘要点击次数: 567 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的 探讨妊娠期糖尿病(gestational diabetes mellitus,GDM)孕妇血清中维生素A、25-羟基维生素D、维生素E的水平及其临床意义。方法 选取在大连大学附属中山医院就诊并诊断为GDM孕妇1000例为实验组；另选取无GDM孕妇1000例为对照组。采用反向高频液相色谱荧光法(high-performance liquid chromatography,HPLC)测定维生素A、E水平；高效液相色谱液相色谱串联质谱法(high-performance liquid chromatography tandem mass spectrometer,HPLC-AS/MS)测定25-羟基维生素D水平。结果 GDM孕妇血清中维生素A水平与无GDM孕妇无明显差异(P>0.05)；GDM孕妇血清中25-羟基维生素D水平均明显低于对照组(P<0.05)；GDM孕妇血清中维生素E水平均明显高于对照组(P<0.05)。GDM孕妇血清中25-羟基维生素D水平与维生素E表达水平呈负相关(r=-0.351,P<0.05)。结论 GDM孕妇血清中25-羟基维生素D水平低,维生素E水平高,且两者有一定相关性,两者可能共同参与GDM的发生发展。 |
| 英文摘要: |
| Objective To investigate the expression levels and clinical significance of vitamin A、25-hydroxyvitamin D、vitamin E in pregnant women with gestational diabetes mellitus. Methods One hundred patients with GDM diagnosed in Zhongshan Hospital Affiliated to Dalian University were selected as experimental group； 100 non-GDM patients were selected as control group. High-performance liquid chromatography (HPLC) was used to determine vitamin A and E levels；high-performance liquid chromatography tandem mass spectrometer(HPLC-AS/MS)was used to determine 25-hydroxyvitamin D levels. Results There was no significant difference in serum vitamin A levels between GDM patients and non-GDM patients (P>0.05)；the serum 25-hydroxyvitamin D levels in GDM patients were significantly lower than those in the control group (P<0.05)；the serum vitamin E levels in GDM patients were significantly higher than those in the control group (P<0.05). The serum level of 25-hydroxyvitamin D in patients with GDM was negatively correlated with the expression of vitamin E (r=-0.351, P<0.05). Conclusion The level of 25-hydroxyvitamin D in patients with GDM is low, and the level of vitamin E is high, and there is a certain correlation between the two, and they may jointly participate in the development of GDM. |
|
View Fulltext
查看/发表评论 下载PDF阅读器 |
| 关闭 |
