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| 血清铁蛋白与非酒精性脂肪肝的相关性研究 |
| Correlation between serum ferritin and nonalcoholic fatty liver disease |
| 投稿时间：2018-07-30 修订日期：2018-08-06 |
| DOI： |
| 中文关键词: 血清铁蛋白 非酒精性脂肪性肝病 |
| 英文关键词: Serum ferritin, Nonalcoholic fatty liver disease |
| 基金项目:江苏省卫计委科研基金项目（BJ15005） |
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| 中文摘要: |
| 目的 探讨血清铁蛋白与非酒精性脂肪肝（NAFLD）的相关性。方法 选择2016年10月至2017年4月我院干保中心诊治的患者299例，根据腹部超声分为有NAFLD组及无NAFLD组。空腹抽血检测肝酶、血脂、血糖、胰岛素、血清铁蛋白、血常规。Pearson相关分析血清铁蛋白与各代谢指标的关系,采用Logistic二元回归分析血清铁蛋白与非酒精性脂肪肝患病率的关系。结果 有NAFLD组血清铁蛋白水平（301.9±206.2）ng/ml明显高于非NAFLD组（176±125.6）ng/ml, t=6.94，P＜0.05。血清铁蛋白与腹围、BMI、Hb、ALT、TG显著正相关（P＜0.05），与HDL-C显著负相关（P＜0.05）。根据血清铁蛋白从低到高分成4等分，Q1(17.8-124.8ng/ml),Q2(125.6-199.4ng/ml),Q3(200.1-339.1ng/ml),Q4(345.6-1074.9ng/ml)，与其对应的NAFLD患病率随之递增，分别为37.3%，52.0%，70.7%，78.4% (趋势P<0.05); 将血清铁蛋白第一分位患脂肪肝的OR设为1.00，校正年龄、性别、BMI、Hb、TG、HDL-C后，第二至第四分位的OR（95%CI）分别为1.994(0.908-4.379)，3.334(1.464-7.595)，3.954(1.578-9.907) (趋势P<0.05)。结论 血清铁蛋白水平与腹围、BMI、Hb、ALT、TG、HDL-C显著相关。血清铁蛋白与非酒精性脂肪肝明显相关。 |
| 英文摘要: |
| Objective To investigate the correlation between serum ferritin and nonalcoholic fatty liver disease (NAFLD). Methods 299 cases of Nanjing Drum Tower Hospital were selected from October 2016 to April 2017. The patients were divided into NAFLD group and NAFLD group according to abdominal ultrasound. The relationship between serum ferritin and various metabolic parameters was analyzed by Pearson correlation analysis and the relationship between serum ferritin and non-alcoholic fatty liver disease rate was analyzed by Logistic regression analysis. Results The serum ferritin level in group NAFLD was significantly higher than that in non NAFLD Group ((301.9 + 206.2) vs (176 + 125.6) ng/ml, t = 6.94, P < 0.01). There was a positive correlation between serum ferritin and waist circumference, BMI, Hb, ALT and TG (P < 0.05), and negatively correlated with HDL-C (P < 0.05). 299 subjects were divided into 4 groups according to the serum ferritin quartiles. which were Q1 (17.8-124.8ng/ml), Q2 (125.6-199.4ng/ml), Q3 (200.1-339.1ng/ml), Q4 (345.6-1074.9ng/ml). The corresponding NAFLD prevalence was 37.3%, 52%, 70.7% and 78.4%. With the increase of serum ferritin, the prevalence of NAFLD increased (trend P<0.05). After correction of age, sex, BMI, Hb, TG, HDL-C, when compared with the first quartile of serum ferritin（reference 1.00)the odds ratio(0R)and 95％confidence interval(CI)for NAFLD across increasing quartiles of serum ferritin were 1.994 (0.908-4.379), 3.334 (1.464-7.595), 3.954 (1.578-9.907) respectively(P for trend<0.05). Conclusion Serum ferritin level was significantly correlated with waist circumference, BMI, Hb, ALT, TG and HDL-C. Serum ferritin was significantly correlated with nonalcoholic fatty liver disease. |
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