|
| SRSF1和Survivin在口腔鳞状细胞癌中的表达及临床意义 |
| Expression and clinical significance of SRSF1 and Survivin in oral squamous cell carcinoma Clinical diagnosis and treatment |
| 投稿时间：2017-12-12 修订日期：2017-12-21 |
| DOI： |
| 中文关键词: 关键词：SRSF1 Survivin 口腔鳞状细胞癌 免疫组织化学 |
| 英文关键词: Key words SRSF1 Survivin oral squamous cell carcinoma Immunohistochemistry |
| 基金项目:基金项目：黑龙江省应用技术研究与开发计划项目（GA14C101-10） |
|
| 摘要点击次数: 286 |
| 全文下载次数: 0 |
| 中文摘要: |
| 摘要 目的： 通过研究人丝氨酸/精氨酸富有剪接因子1（SRSF1）和凋亡抑制因子（Survivin）在口腔鳞状细胞癌（OSCC）组织和正常口腔黏膜（NOM）中的表达，探究两因子之间OSCC发生发展中的作用及相关性。方法： 采用免疫组织化学SP法，检测60例OSCC组织、20例正常NOM组织中两种因子的表达情况，并结合组织学分级、淋巴结转移及临床分期等相关的信息进行相关性分析。结果： 在NOM中SRSF1和Survivin低表达，在OSCC组织中均高表达，比例分别为68.3%和60%。SRSF1和Survivin与淋巴结转移、组织学分级以及临床分期之间存在统计学差异（P<0.05）；并且在OSCC组织中二者之间表达存在着显著正相关性，（r=0.541，P<0.05）。结论： SRSF1 和Survivin在OSCC中均高表达，与口腔鳞癌的发生、发展密切相关并具有协同作用。 |
| 英文摘要: |
| 【Abstract】 Objective: Through human serine/arginine rich splicing factor 1 (SRSF1) and apoptosis inhibiting factor (Survivin) in oral squamous cell carcinoma (OSCC) tissues and the expression of normal oral mucosa (NOM), to explore its role in the development of OSCC between two factors and correlation . Methods: Immunohistochemical SP method was used to detect the expression of two factors in 60 cases of OSCC and 20 cases of normal NOM, and correlation analysis was made according to histological grading, lymph node metastasis and clinical stage. Results: SRSF1 and Survivin were lowly expressed in NOM, and were highly expressed in OSCC tissues, and the proportion was 68.3% and 60% respectively. There was a significant difference between SRSF1 and Survivin in lymph node metastasis, histological grade and clinical stage (P<0.05), and there was a significant positive correlation between the two expressions in OSCC tissues (r=0.541, P<0.05). Conclusion: SRSF1 and Survivin are highly expressed in OSCC, which are closely related to the occurrence and development of oral squamous cell carcinoma and have synergistic effect. |
|
View Fulltext
查看/发表评论 下载PDF阅读器 |
| 关闭 |
