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整合素αvβ3与恶性肿瘤侵袭转移关系的研究进展 |
Research progress of integrins and invasion and metastasis of malignant tumor relationship |
投稿时间:2015-05-13 修订日期:2015-05-13 |
DOI: |
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英文关键词: |
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中文摘要: |
【】整合素(integrins)是一类介导细胞与细胞外基质、细胞与细胞间粘附的细胞粘附分子, 研究证实整合素与肿瘤转移有着密切关系。整合素αvβ3是整合素家族中的一种重要分子,肿瘤血管内皮细胞αvβ3的表达水平在肿瘤侵袭转移及血管生成中起着重要作用,调节αvβ3的表达水平可明显抑制肿瘤的侵袭转移及肿瘤组织中新生血管的形成。深入研究整合素αvβ3的分子机制可为肿瘤治疗提供新的治疗靶点。 |
英文摘要: |
【】Integrins are cell adhesion molecules which can mediate the interactions between cell to cell and cell to extracellular matrix. Expression of integrins are related to the invasion of tumor cells. The integrinαvβ3 is an important member of the integrins family. The expression of integrinαvβ3in vascular endothelial cells plays an important role in the invasion of tumor cells and vascularization. To control the expression of integrinαvβ3 can obviously inhibit the invasion of tumor and the vascularization. Further investigation of integrinαvβ3will provide a new target for the treatment of tumors. |
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