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| 神经酰胺诱导细胞凋亡的机制研究进展 |
| Progression of mechanism of ceramide-induced apoptosis |
| 投稿时间：2014-06-26 修订日期：2014-06-26 |
| DOI： |
| 中文关键词: 神经酰胺 鞘脂类 细胞凋亡 Jun氨基末端激酶 P53 |
| 英文关键词: ceramide sphingomyelin apoptosis c-Jun N-terminal kinase P53 |
| 基金项目:国家自然科学基金资助项目(编号：81373465) |
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| 中文摘要: |
| 【】神经酰胺(ceramide,Cer)作为一种神经鞘磷脂分子,不仅是细胞膜的组成成分,而且可以作为各种信号转导途径的第二信使,参与细胞增殖、分化、衰老和凋亡等生命活动的调节。Cer可通过激活蛋白激酶、组织蛋白酶D、Jun氨基末端激酶、蛋白磷酸酶1(Protein phosphatase1,PP1)和蛋白磷酸酶2A(Protein phosphatase2A,PP2A)等介导细胞凋亡。本文综述近年来有关Cer在应激反应级联以及细胞凋亡中的研究进展。 |
| 英文摘要: |
| 【】Ceramide as a sphingomyelin molecules, is not only the composition of cell membranes, but also as a second messenger in a variety of signal transduction pathways involved in regulating activities of life such as cell proliferation, differentiation, senescence and apoptosis .Ceramide mediated apoptosis through activation of protein kinase , cathepsin D, c-Jun N-terminal kinase, protein phosphatase 1 and protein phosphatase 2A , etc. This review describes the known role of ceramide in stress response cascade and apoptosis. |
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