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| 贝伐单抗辅助的23G玻璃体切割术治疗严重增生性糖尿病视网膜病变的疗效观察* |
| A Therapeutic Effect observation of23 G Pars Plana Vitrectomy Assisted by Bevacizumab |
| 投稿时间：2013-05-14 修订日期：2013-05-20 |
| DOI： |
| 中文关键词: 贝伐单抗/阿伐斯汀 严重增生性糖尿病视网膜病变 药物辅助玻璃体手术 手术效果 |
| 英文关键词: Bevacizumab/avastin severe prolierative diabetic retinopathy pars plana vitrectomy |
| 基金项目:2011年国家自然基金面上项目(81070739) |
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| 中文摘要: |
| 目的：探讨术前注射贝伐单抗对23G玻璃体切割手术治疗严重增生性糖尿病视网膜病变患者效果的影响。 |
| 英文摘要: |
| In 2011，the number of diabetics in China is up to 92.4 million. As a common complication of diabetes ,Diabetic retinopathy (DR, diabetic retinopathy) has become one of the major causes of adult acquired blindness and its prevalence was 37% in the diabetic population. Traction retinal detachment and vitreous hemorrhage are the Characteristic pathophysiological process of Proliferative diabetic retinopathy which is known as high blinding rate and high difficulty of operation, Objective: To evaluate the effect of preoperative intravitreal bevacizumab injection (IVB) 3-7 days before 23 G pars plana vitrectomy (PPV) for severe proliferative diabetic retinopathy patients. Methods: To retrospect and study the cases. 70 patients 70 eyes with severe proliferative diabetic retinopathy who were divided into group A(23 G pars plana vitrectomy assisted by preoperative intravitreal bevacizumab injection , 21 patients 21 eyes) and group B(23G pars plana vitrectomy,49 patients 49 eyes). Main outcomes measures were visual acuity, operation time, incidence of iatrogenic retinal breaks , endodiathermy, and postoperative bleeding. Results: At 3 months after surgery, the visual acuity of both group improved significantly(P<0.05). The average operation time is 74 minutes and 85 minutes in group A and group B respectively(P>0.05) , Iatrogenic retinal breaks were reported in 1 case in group A and 16 cases in group B (P<0.05). Endodiathermy was employed in 3 cases in group A and 25 cases in group B (P<0.05). Postoperative bleeding was reported in 1 case in group A while 20 cases were reported in group B (P<0.05). Conlusion: In our 70 severe proliferative diabetic retinopathy patients included retrospective study, we found that preoperative intravitreal 1.25 mg/0.05 ml of bevacizumab injection 3-7 days before surgery had a significant effect to the 23 G three channel pars plana vitrectomy：it could reduce the incidence of iatrogenic retinal break and postoperative bleeding、the employment of endodiathermy. |
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