| 郭晶晶,杨振林,张 旭,李今子.铁死亡在癫痫中的研究进展[J].,2025,(18):3032-3040 |
| 铁死亡在癫痫中的研究进展 |
| Research Progress on Ferroptosis in Epilepsy |
| 投稿时间：2025-06-04 |
| DOI：10.13241/j.cnki.pmb.2025.18.021 |
| 中文关键词: 癫痫 铁死亡 调控机制 研究进展 治疗 |
| 英文关键词: Epilepsy Ferroptosis Regulatory Mechanisms Research Progress Treatment |
| 基金项目:吉林省卫生健康科技能力提升项目（2023JC022）；吉林省教育厅科技项目-教育厅重点科技项目（JJKH20240639KJ） |
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| 中文摘要: |
| 摘要：癫痫作为神经系统第二大常见病，具有发病原因的多样性，病情的复杂性、难治性和致残性的特点，对患者的家庭和社会生活带来沉重负担，而长期反复的癫痫发作及控制不佳，导致神经元的失活和患者认知障碍的产生，找寻新的靶向治疗方式和探寻癫痫对神经元损伤的分子调控机制变得越来越重要。铁死亡是一种由亚铁离子介导可调节的新型细胞程序性死亡方式，其特点是亚铁离子的储积、有害脂质过氧化物及致命活性氧的积累，并导致线粒体功能和结构受损。随着近来对铁死亡的深入研究，发现抑制铁死亡相关靶点及途径可以减轻癫痫的发作及进展和保护神经元的作用。本文就铁死亡的分子机制、相关调控，在癫痫中的作用和近年来相关治疗进展行简要概述。 |
| 英文摘要: |
| ABSTRACT: Epilepsy, as the second most common neurological disease, has diverse causes, complex, difficult to treat, and disabling characteristics, which impose a heavy burden on patients' families and social life. Long term recurrent epileptic seizures and poor control lead to neuronal inactivation and cognitive impairment in patients. Therefore, it is becoming increasingly important to find new targeted treatment methods and explore the molecular regulatory mechanisms of epilepsy on neuronal damage. Iron induced cell death is a novel programmed cell death mediated by ferrous ions, characterized by the accumulation of ferrous ions, harmful lipid peroxides, and lethal reactive oxygen species, leading to damage to mitochondrial function and structure. With recent in-depth research on ferroptosis, it has been found that inhibiting ferroptosis related targets and pathways can alleviate seizures and progression of epilepsy and protect neurons. This article provides a brief overview of the molecular mechanisms and related regulation of ferroptosis, its role in epilepsy, and recent advances in related treatments. |
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