| 成 双,陈 维,黄亚田,郭 欣,龚宪成.氨甲环酸联合缩宫素预防剖宫产后
再次妊娠患者产后出血的效果[J].,2025,(5):918-923 |
| 氨甲环酸联合缩宫素预防剖宫产后
再次妊娠患者产后出血的效果 |
| The Effect of Tranexamic Acid Combined with Oxytocin on Preventing Postpartum Hemorrhage in Patients with Repregnancyafter Cesarean Section |
| 投稿时间：2024-11-10 |
| DOI：10.13241/j.cnki.pmb.2025.05.014 |
| 中文关键词: 氨甲环酸 缩宫素 产后出血 剖宫产 再次妊娠 |
| 英文关键词: Tranexamic acid Oxytocin Postpartum hemorrhage Cesarean section Repregnancy |
| 基金项目:山东省保健协会项目（SFYXH-20240011） |
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| 中文摘要: |
| 摘要 目的：探讨TXA联合缩宫素预防剖宫产后再次妊娠患者PPH的效果。方法：选入2022年1月至2024年4月在我院行剖宫产后再次妊娠的96例产妇，根据PPH预防用药方案不同分为对照组和观察组，各48例，分别予以缩宫素、缩宫素+ TXA治疗。对比两组术后出血量、PPH发生率、凝血功能指标以及不良反应情况等。结果：观察组产后2 h、24 h出血量较对照组少，PPH发生率较对照组低（P＜0.05）；相较于产前，两组产后24 h的PT、APTT明显降低，FIB显著升高（P＜0.05），而观察组降低/升高幅度明显大于对照组（P＜0.05）；与对照组相比，观察组宫缩持续时间、宫底平均下降速度高，血性恶露持续时间低（P＜0.05）；两组不良反应发生率无明显差异（18.75% vs. 22.92%，P＞0.05）。结论：TXA联合缩宫素可有效改善剖宫产后再次妊娠孕妇的凝血功能，减少出血量及PPH发生率，促进子宫复旧，且安全性良好。 |
| 英文摘要: |
| ABSTRACT Objective: To explor the effect of TXA combined with oxytocin in preventing PPH in patients with recurrent pregnancy after cesarean section. Methods: 96 postpartum women who underwent cesarean section in our hospital from January 2022 to April 2024 were selected and divided into a matched group and an observation group according to different PPH prevention medication regimens, with 48 cases in each group. They were treated with oxytocin and oxytocin+TXA, respectively. Compare the postoperative bleeding volume, PPH incidence, coagulation function indicators, and adverse reactions between the two groups. Results:The observation group had less bleeding and lower incidence of PPH at 2 and 24 hours postpartum compared to the matched group (P<0.05). Compared with pre delivery, PT and APTT were significantly reduced and FIB was significantly increased in both groups 24 hours after delivery (P<0.05), while the observation group showed a significantly greater decrease/increase than matched group (P<0.05). The duration of uterine contractions and the average descent rate of the uterine floor in the observation group were high, while the duration of bloody lochia was low (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (18.75% vs. 22.92%, P>0.05). Conclusion: TXA combined with oxytocin can effectively improve the coagulation function, reduce bleeding and PPH incidence, promote uterine involution, and have good safety in pregnant women with repregnancy after cesarean section. |
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