| .3D-ASL联合mRS评分对醒后卒中患者降纤治疗疗效预测研究[J].,2024,(24):4766-4768 |
| 3D-ASL联合mRS评分对醒后卒中患者降纤治疗疗效预测研究 |
| Projections of Therapeutic Effects of Defibrillation in Patients with Wake-up Stroke Based on 3D-ASL Combined with mRS Score |
| 投稿时间：2024-08-09 修订日期：2024-08-26 |
| DOI：10.13241/j.cnki.pmb.2024.24.042 |
| 中文关键词: 动脉自旋标记 脑血流量 急性脑梗死 醒后卒中 预后 |
| 英文关键词: Arterial spin marker Cerebral blood flow Acute cerebral infarction Wake-up stroke Prognosis |
| 基金项目:国家自然科学基金青年项目（81601092） |
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| 中文摘要: |
| 摘要 目的：动脉自旋标记（Arterial Spin Labeling, ASL）是一种在组织水平无创、定量的脑灌注磁共振成像技术，能够在早期对急性脑梗死区血流量变化进行监测。本研究对3D-ASL技术在醒后卒中缺血区绝对脑血流量（aCBF）和相对脑血流量（rCBF）的诊断准确性和敏感性进行探究，并分析相关参数值对患者预后的评估价值。方法：选取我院2019年1月至2020年12月收治的醒后卒中患者58例（男性38人，女性20人），急诊入院行头部磁共振TIWI、T2WI、DWI、MRA、3D-ASL，并进行CBF和ADC测量，计算rCBF等参数值；三个月后根据改良的Rankin（mRS）量表，对患者进行评估，并对收集的数据进行统计分析。结果：根据mRS量表，预后良好组（mRS≤2）36人，占比62%；预后不良组（mRS≥3）22人，占比37.9%。aCBF对预后良好组的评估方面有较好的诊断价值；预后良好组与预后不良组相比较，rCBF值更高；ROC曲线提示，当临界值aCBF=17.90，rCBF=40.9%时，灵敏度和特异度之和最高。结论：醒后卒中缺血病灶区存在不同程度的灌注减低，3D-ASL对醒后卒中患者的预后具有可靠的预测作用。 |
| 英文摘要: |
| ABSTRACT Objective: Arterial spin labeling (Arterial Spin Labeling, ASL) is a non-invasive, quantitative brain perfusion MR imaging technique at the tissue level that can monitor blood flow changes in the area of acute cerebral infarction at an early stage. This study explores the diagnostic accuracy and sensitivity of 3D-ASL techniques in absolute brain blood flow (aCBF) and relative brain blood flow (rCBF) in wake stroke ischemia and analyzed the evaluation value of relevant parameter values for patient prognostic. Methods: selected 58 wake stroke patients (38 men and 20 women) from January 2019 to December 2020, head MRI TIWI, T2WI, DWI, MRA, 3D-ASL, CBF and ADC, calculated rCBF and other parameters. After three months, patients were evaluated on improved Rankin (mRS) scale and analyzed collected data. Results: According to the mRS scale, there were 36 people, representing 62% and 22 people(mRS≥ 3), representing 37.9%. aCBF has good diagnostic value in the evaluation of prognostic groups; higher rCBF values compared to prognostic groups; ROC curve indicates highest sensitivity and specificity when critical values aCBF=17.90, rCBF=40.9%. Conclusion:Different degrees of perfusion decreased in the waking stroke ischemic lesion area, and 3D-ASL was a reliable predictor on the prognosis of patients with waking stroke. |
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