| .血清ALP、Copeptin及cTnⅠ水平与急性ST抬高型心肌梗死患者
PCI术后左心室壁瘤形成的关系研究[J].,2024,(24):4759-4762 |
| 血清ALP、Copeptin及cTnⅠ水平与急性ST抬高型心肌梗死患者
PCI术后左心室壁瘤形成的关系研究 |
| Relationship between Serum ALP, Copeptin and cTnI Levels and Left Ventricular Aneurysm Formation after PCI in Acute ST-Elevation Myocardial Infarction Patients |
| 投稿时间：2024-08-21 修订日期：2024-09-11 |
| DOI：10.13241/j.cnki.pmb.2024.24.039 |
| 中文关键词: 急性ST抬高型心肌梗死 左心室壁瘤 碱性磷酸酶 和肽素 心肌肌钙蛋白Ⅰ 经皮冠状动脉介入术 列线图预测模型 |
| 英文关键词: Acute ST-elevation myocardial infarction Left ventricular aneurysm Alkaline phosphatase Copeptin Cardiac troponin I Percutaneous coronary intervention Nomogram prediction model |
| 基金项目:陕西省重点研发计划（2023-YBSF-674） |
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| 中文摘要: |
| 摘要 目的：探讨血清碱性磷酸酶（ALP）、和肽素（Copeptin）及心肌肌钙蛋白Ⅰ（cTnⅠ）水平与急性ST抬高型心肌梗死（STEMI）患者经皮冠状动脉介入（PCI）术后左心室壁瘤（LVA）形成的关系，并构建STEMI患者PCI术后LVA形成的列线图（Nomogram）预测模型。方法：287例STEMI患者根据PCI术后是否形成LVA分为LVA组（n=63）和非LVA组（n=224），多因素Logistic回归分析影响因素；并构建Nomogram预测模型。采用受试者工作特征（ROC）曲线评估预测价值。结果：LVA组血清ALP、Copeptin、cTnⅠ水平高于非LVA组（P＜0.05）。心率（HR）、肌酸激酶同工酶（CKMB）、N末端B型脑钠肽（NTpro-BNP）、血清ALP、Copeptin、cTnⅠ水平升高是STEMI患者PCI术后LVA形成的独立危险因素（P＜0.05）。基于上述危险因素构建的Nomogram预测模型的预测曲线与理想曲线贴合度良好。结论：PCI术后形成LVA的STEMI患者血清ALP、Copeptin、cTnⅠ呈异常高表达，HR、CKMB、NTpro-BNP、血清ALP、Copeptin、cTnⅠ水平升高为STEMI患者PCI术后LVA形成的独立危险因素。基于上述危险因素构建的Nomogram预测模型对STEMI患者PCI术后LVA形成具有较高的预测价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between the levels of serum alkaline phosphatase (ALP), copeptin (copeptin) and cardiac troponin I (cTnI) and the formation of left ventricular aneurysm (LVA) after percutaneous coronary intervention (PCI) in acute ST-elevation myocardial infarction (STEMI) patients, and to construct a nomogram (Nomogram) prediction model for LVA formation after PCI in STEMI patients. Methods: 287 STEMI patients were divided into LVA group (n=63) and non-LVA group (n=224) according to whether LVA was formed after PCI. Influencing factors were analyzed by multivariate Logistic regression analysis; and the Nomogram prediction model was constructed. The predictive value was evaluated by receiver operating characteristic(ROC) curve. Results: The levels of serum ALP, Copeptin and cTnI in LVA group were higher than those in non-LVA group(P<0.05). Elevated heart rate (HR), creatine kinase isoenzyme (CKMB), N-terminal B-type brain natriuretic peptide (NTpro-BNP), serum ALP, Copeptin and cTnI levels were independent risk factors for LVA formation after PCI in STEMI patients(P<0.05). The prediction curve of the Nomogram prediction model based on the above risk factors fits well with the ideal curve. Conclusion: The levels of serum ALP, Copeptin and cTnI are abnormally high in STEMI patients with LVA after PCI, the elevated levels of HR, CKMB, NTpro-BNP, serum ALP, Copeptin and cTnI are independent risk factors for LVA formation after PCI in STEMI patients. The Nomogram prediction model based on the above risk factors has a high predictive value for LVA formation in STEMI patients after PCI. |
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