| .外周静脉血miR-574-5p、血清Fibulin-3在腹主动脉瘤中的表达
及其与腔内血栓厚度、术后并发症的相关性分析[J].,2024,(24):4756-4758 |
| 外周静脉血miR-574-5p、血清Fibulin-3在腹主动脉瘤中的表达
及其与腔内血栓厚度、术后并发症的相关性分析 |
| Expression of miR-574-5p in Peripheral Venous Blood and Serum Fibulin-3 in Abdominal Aortic Aneurysm and Their Correlation with Intraluminal Thrombus Thickness and Postoperative Complications |
| 投稿时间：2024-08-20 修订日期：2024-09-14 |
| DOI：10.13241/j.cnki.pmb.2024.24.038 |
| 中文关键词: 腹主动脉瘤 miR-574-5p Fibulin-3 |
| 英文关键词: Abdominal aortic aneurysm miR-574-5p Fibulin-3 |
| 基金项目:辽宁省教育厅2021年科学研究面上项目（LJKZ0859） |
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| 中文摘要: |
| 摘要 目的：本研究旨在探讨外周静脉血miR-574-5p和血清Fibulin-3在腹主动脉瘤（AAA）中的表达及其与腔内血栓厚度和术后并发症的相关性。方法：选取112例AAA患者和40例健康对照组，对比相关指标并分析影响因素及诊断价值。结果：AAA患者组的miR-574-5p和Fibulin-3表达水平高于健康对照组（P<0.001）。多因素Logistic回归分析显示，miR-574-5p表达水平高是患者腔内血栓厚度增加的独立危险因素，Fibulin-3表达水平低是患者并发症增加的独立危险因素(P<0.05)。ROC曲线分析结果显示，miR-574-5p在诊断AAA患者腔内血栓厚度增加中的AUC为0.841，截断值为1.826，特异性为73.5%，敏感度为89.0%；Fibulin-3在预测AAA患者术后并发症中的AUC为0.933，截断值为3.244，特异性为85.6%，敏感度为92.3%。结论：miR-574-5p和Fibulin-3在AAA患者中的表达水平显著升高，且miR-574-5p与腔内血栓厚度显著相关，Fibulin-3与术后并发症显著相关。miR-574-5p和Fibulin-3可作为AAA的潜在生物标志物，为其诊断和预后提供新思路。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression of peripheral venous blood miR-574-5p and serum Fibulin-3 in abdominal aortic aneurysm (AAA) and its correlation with intracavitary thrombus thickness and postoperative complications. Methods: 112 AAA patients and 40 healthy controls were selected to compare the relevant indicators and analyze the influencing factors and diagnostic value. Results: The expression levels of miR-574-5p and Fibulin-3 were higher than in healthy controls (P<0.001). Multivariate Logistic regression analysis showed that high expression level of miR-574-5p was an independent risk factor for increased lumen thrombus thickness in patients, and low Fibulin-3 expression was an independent risk factor for increased complications in patients (P<0.05). ROC curve analysis showed that the AUC of miR-574-5p in the diagnosis of AAA was 0.841, cut-off value of 1.826, specificity of 73.5%, sensitivity of 89.0%; Fibulin-3 had AUC of 0.93 in predicting postoperative complications of AAA patients 0.33, cut-off value of 3.244, specificity of 85.6%, and sensitivity of 92.3%. Conclusion: The expression levels of miR-574-5p and Fibulin-3 were significantly increased in AAA patients, and miR-574-5p was significantly correlated with intracavitary thrombus thickness, and Fibulin-3 was significantly correlated with postoperative complications. miR-574-5p and Fibulin-3 can be used as potential biomarkers for AAA, providing new ideas for its diagnosis and prognosis. |
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