| .血清lncRNA MEG3、miR-424-5p水平与急性呼吸窘迫综合征患儿
病情严重程度和预后的关系[J].,2024,(24):4746-4748 |
| 血清lncRNA MEG3、miR-424-5p水平与急性呼吸窘迫综合征患儿
病情严重程度和预后的关系 |
| Relationship between Serum lncRNA MEG3 and miR-424-5p Levelsand the Severity and Prognosis of Children with Acute Respiratory Distress Syndrome |
| 投稿时间：2024-09-09 修订日期：2024-10-10 |
| DOI：10.13241/j.cnki.pmb.2024.24.035 |
| 中文关键词: 急性呼吸窘迫综合征 lncRNA MEG3 miR-424-5p 病情严重程度 预后 |
| 英文关键词: Acute respiratory distress syndrome lncRNA MEG3 miR-424-5p Severity of disease Prognosis |
| 基金项目:江苏省妇幼健康科研项目（F202065）；南通市科技项目（MS22022026） |
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| 中文摘要: |
| 摘要 目的：分析血清长链非编码RNA MEG3（lncRNA MEG3）、微小核糖核酸-424-5p（miR-424-5p）在急性呼吸窘迫综合征（ARDS）患儿中的表达及与其病情严重程度和预后的关系。方法：根据氧合指数（OI）将263例ARDS患儿分为轻度组（n=101）、中度组（n=105）和重度组（n=57），再依据预后情况将其分为存活组（n=167）和死亡组（n=96）。比较轻度组、中度组和重度组血清lncRNA MEG3、miR-424-5p水平；Pearson法分析血清lncRNA MEG3、miR-424-5p水平与患儿病情严重程度的相关性；单因素和多因素COX风险回归模型分析ARDS患儿死亡的影响因素。结果：与轻度组和中度组比较，重度组血清lncRNA MEG3水平明显更低，miR-424-5p水平、OI明显更高（P＜0.05）；与轻度组比较，中度组lncRNA MEG3水平显著降低，miR-424-5p水平、OI显著升高（P＜0.05）；血清lncRNA MEG3与OI呈负相关，血清miR-424-5p与OI呈正相关（P＜0.05）；OI、miR-424-5p、白介素-6（IL-6）、白介素-17（IL-17）、肿瘤坏死因子-α（TNF-α）是影响ARDS患儿预后的独立危险因素，lncRNA MEG3是影响ARDS患儿预后的独立保护因素（P＜0.05）。结论：血清lncRNA MEG3、miR-424-5p与ARDS患儿病情严重程度及预后密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the expression of serum long non-coding RNA MEG3 (lncRNA MEG3) and microRNA-424-5p (miR-424-5p) in children with acute respiratory distress syndrome (ARDS) and their relationship with the severity and prognosis of the disease. Methods: 263 children with ARDS were divided into mild group (n=101), moderate group (n=105) and severe group (n=57) according to the oxygenation index (OI). According to the prognosis, they were divided into survival group (n=167) and death group (n=96). The levels of serum lncRNA MEG3 and miR-424-5p in mild group, moderate group and severe group were compared. The correlation between serum lncRNA MEG3, miR-424-5p levels and the severity of the disease in children were analyzed by Pearson method. The influencing factors of death in children with ARDS were analyzed by univariate and multivariate COX risk regression models. Results: Compared with mild group and moderate group, the serum lncRNA MEG3 level in severe group was significantly lower, the miR-424-5p level and OI were significantly higher(P<0.05). Compared with mild group, the level of lncRNA MEG3 in moderate group was significantly decreased, and the level of miR-424-5p and OI were significantly increased (P<0.05). Serum lncRNA MEG3 was negatively correlated with OI, and serum miR-424-5p was positively correlated with OI (P<0.05). OI, miR-424-5p, interleukin-6 (IL-6), interleukin-17(IL-17) and tumor necrosis factor-α(TNF-α) were independent risk factors affecting the prognosis of children with ARDS, and lncRNA MEG3 was an independent protective factor affecting the prognosis of children with ARDS(P<0.05). Conclusion: Serum lncRNA MEG3 and miR-424-5p are closely related to the severity and prognosis of children with ARDS. |
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