| .不同肠内营养时机对重症急性胰腺炎患者营养状况、肠黏膜屏障功能
及炎症免疫平衡的影响[J].,2024,(24):4740-4742 |
| 不同肠内营养时机对重症急性胰腺炎患者营养状况、肠黏膜屏障功能
及炎症免疫平衡的影响 |
| Effects of Different Enteral Nutrition Timing on Nutritional Status,Intestinal Mucosal Barrier Function and Inflammatory Immune Balancein Patients with Severe Acute Pancreatitis |
| 投稿时间：2024-09-09 修订日期：2024-10-12 |
| DOI：10.13241/j.cnki.pmb.2024.24.033 |
| 中文关键词: 肠内营养 重症急性胰腺炎 营养状况 肠黏膜屏障功能 炎症反应 免疫反应 |
| 英文关键词: Enteral nutrition Severe acute pancreatitis Nutritional status Intestinal mucosal barrier function Inflammatory reaction Immune reaction |
| 基金项目:广东省医学科研基金项目（A2018036） |
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| 摘要点击次数: 12 |
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| 中文摘要: |
| 摘要 目的：探讨重症急性胰腺炎（SAP）患者在不同肠内营养时机干预下，患者肠黏膜屏障功能、营养状况及炎症免疫平衡的改善情况。方法：根据随机数字表法将120例SAP患者分为A组（入院48 h内行肠内营养）、B组（入院2~5 d行肠内营养）、C组（入院5 d后行肠内营养），各40例。对比三组营养状况、肠黏膜屏障功能、炎症指标水平、免疫功能。结果：治疗后，A组、B组血清白蛋白（ALB）、前白蛋白（PA）、转铁蛋白（TRF）水平高于C组，且A组高于B组（P＜0.05）。治疗后，A组、B组血清内毒素、二胺氧化酶（DAO）、D-乳酸水平低于C组，且A组低于B组（P＜0.05）。治疗后，A组、B组血清血清C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、降钙素原（PCT）水平低于C组，且A组低于B组（P＜0.05）。治疗后，A组、B组血清免疫球蛋白A（IgA）、免疫球蛋白G（IgG）、免疫球蛋白M（IgM）水平高于C组，且A组高于B组（P＜0.05）。结论：在入院后48 h内给予SAP患者肠内营养，有利于早期病情的缓解，同时可改善营养状况、肠道功能，减轻炎症免疫反应。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the improvement of intestinal mucosal barrier function, nutritional status and inflammatory immune balance in patients with severe acute pancreatitis (SAP) under different enteral nutrition timing interventions. Methods: 120 patients with SAP were divided into group A(enteral nutrition within 48 hours after admission), group B(enteral nutrition 2~5 days after admission) and group C(enteral nutrition 5 days after admission) according to the random number table method, with 40 cases in each group. The nutritional status, intestinal mucosal barrier function, inflammatory index level and immune function in three groups were compared. Results: After treatment, serum albumin (ALB), prealbumin (PA) and transferrin (TRF) levels in group A and group B were higher than those in group C, and those in group A were higher than those in group B(P<0.05). After treatment, serum endotoxin, diamine oxidase (DAO) and D-Lactate levels in group A and group B were lower than those in group C, and those in group A were lower than those in group B (P<0.05). After treatment, serum C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and procalcitonin (PCT) levels in group A and group B were lower than those in group C, and those in group A were lower than those in group B(P<0.05). After treatment, serum immunoglobulin A (IgA), immunoglobulin G (IgG) and immunoglobulin M (IgM) in group A and group B levels were higher than those in group C, and those in group A were higher than those in group B (P<0.05). Conclusion: Enteral nutrition given to patients with SAP within 48 h after admission is conducive to early remission of the disease, while improving nutritional status, intestinal function, and reducing inflammatory immune reaction. |
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