| .超声造影联合超声弹性成像对原发性肝癌微血管侵犯的预测价值研究[J].,2024,(24):4700-4703 |
| 超声造影联合超声弹性成像对原发性肝癌微血管侵犯的预测价值研究 |
| The Predictive Value of Contrast-enhanced Ultrasound Combinedwith Ultrasound Elastography for Microvascular Invasionof Primary Liver Cancer |
| 投稿时间：2024-07-16 修订日期：2024-08-15 |
| DOI：10.13241/j.cnki.pmb.2024.24.022 |
| 中文关键词: 原发性肝癌 微血管侵犯 超声造影 超声弹性成像 |
| 英文关键词: Primary liver cancer Microvascular invasion Contrast-enhanced ultrasound Ultrasonic elastography |
| 基金项目:2023年度河北省医学科研计划项目（20231985） |
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| 中文摘要: |
| 摘要 目的：探讨超声造影联合超声弹性成像对原发性肝癌微血管侵犯（MVI）的预测价值。方法：回顾性分析2021年2月~2024年2月我院肝胆外科收治的80例原发性肝癌患者的临床资料。依据术后病理学结果是否观测到MVI分为MVI阴性组（n=43）和MVI阳性组（n=37）。所有患者术前均行超声造影、超声弹性成像检查，术后进行病理学检查。比较两组超声造影特征及超声弹性成像评分；以术后病理学结果为"金标准"，比较超声造影、超声弹性成像单独及二者联合检查的敏感度、特异度、阳性预测值、阴性预测值及准确度。结果：与MVI阴性组相比，MVI阳性组瘤周强化比例更高（P＜0.05），廓清时间更短（P＜0.05）；门静脉期及延迟期低增强比例更高（P＜0.05）。以病理学诊断为"金标准"，两种检查结果任一阳性者判断为阳性，将两种检查方法及二者联合进行两两比较，结果显示：二者联合的敏感度均高于二者单独检查（P＜0.05），二者联合检查的阴性预测值高于超声造影检查（P＜0.05）。结论：超声造影联合超声弹性成像二者均可在术前有效预测原发性肝癌患者MVI情况，二者联合使用时诊断效能可进一步提高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the predictive value of contrast-enhanced ultrasound combined with ultrasound elastography for microvascular invasion (MVI ) of primary liver cancer. Methods: The clinical data of 80 patients with primary liver cancer admitted to the Department of Hepatobiliary Surgery of our hospital from February 2021 to February 2024 were retrospectively analyzed. According to the postoperative pathological results, the patients were divided into MVI negative group (n=43) and MVI positive group (n=37). All patients underwent contrast-enhanced ultrasound and ultrasound elastography before operation, and pathological examination after operation. The characteristics of contrast-enhanced ultrasound and ultrasonic elastography scores were compared between the two groups. The postoperative pathological results were used as the ' gold standard ' to compare the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of contrast-enhanced ultrasound, ultrasound elastography and their combination. Results: Compared with the MVI negative group, the MVI positive group had a higher proportion of peritumoral enhancement (P<0.05) and a shorter clearance time (P<0.05). The proportion of low enhancement in portal vein phase and delayed phase was higher (P<0.05). With pathological diagnosis as the ' gold standard ', any positive result of the two examinations was judged to be positive. The two examination methods and the combination of the two were compared in pairs. The results showed that the sensitivity of the combination of the two was higher than that of the two alone (P<0.05). The negative predictive value of the combined examination was higher than that of contrast-enhanced ultrasound (P<0.05). Conclusion: Both contrast-enhanced ultrasound and ultrasound elastography can effectively predict MVI in patients with primary liver cancer before operation, and the diagnostic efficacy can be further improved when they are combined. |
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