| .腹泻型肠易激综合征血清吲哚-2，3-双加氧酶与焦虑抑郁
和中医证型的关系研究[J].,2024,(24):4673-4675 |
| 腹泻型肠易激综合征血清吲哚-2，3-双加氧酶与焦虑抑郁
和中医证型的关系研究 |
| Study on the Relationship between Serum Indole-2,3-dioxygenase with Anxiety, Depression and Traditional Chinese Medicine Syndromes Typein Diarrhea-predominant Irritable Bowel Syndrome |
| 投稿时间：2024-08-22 修订日期：2024-09-20 |
| DOI：10.13241/j.cnki.pmb.2024.24.014 |
| 中文关键词: 腹泻型肠易激综合征 中医证型 吲哚-2,3-双加氧酶 焦虑抑郁 |
| 英文关键词: Diarrhea-predominant irritable bowel syndrome Traditional chinese medicine syndromes type Indole-2,3-dioxygenase Anxiety and depression |
| 基金项目:首都卫生发展科研专项项目（首发2022-1-4201） |
|
|
| 摘要点击次数: 12 |
| 全文下载次数: 4 |
| 中文摘要: |
| 摘要 目的：研究腹泻型肠易激综合征（IBS-D）患者血清吲哚-2，3-双加氧酶（IDO）与焦虑抑郁和不同中医证型的关系。方法：选择121名IBS-D患者作为IBS-D组和100名体检健康的志愿者为对照组。IBS-D患者根据抑郁情况分为IBS-D伴抑郁组、IBS-D无抑郁组；根据焦虑情况分为IBS-D伴焦虑组、IBS-D无焦虑组。检测血清IDO水平并计算IDO活化指数，分析IDO水平、IDO活化指数与IBS-D患者各中医证型的关系。结果：IBS-D组的血清IDO水平、IDO活化指数均高于对照组（P＜0.05）。IBS-D伴抑郁组血清IDO水平、IDO活化指数高于IBS-D无抑郁组（P＜0.05）；IBS-D伴焦虑组血清IDO水平、IDO活化指数高于IBS-D无焦虑组（P＜0.05）。肝郁脾虚型、脾胃湿热型、脾虚湿阻型血清IDO水平较对照组升高（P＜0.05），脾肾阳虚型、肝郁脾虚型、脾虚湿阻型、脾胃湿热型IDO活化指数较对照组升高（P＜0.05）。血清IDO水平与肝郁脾虚型呈正相关，与脾肾阳虚型、肠道燥热型呈负相关（P＜0.05）。IDO活化指数与肝郁脾虚型呈正相关，与肠道燥热型、脾虚湿阻型呈负相关（P＜0.05）。结论：IBS-D患者血清IDO水平以及IDO活化水平升高，与患者焦虑、抑郁状态和中医证型有关，血清IDO水平及活化水平可为临床从辨证治疗IBS-D提供参考。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relationship between serum indole-2,3-dioxygenase (IDO) with anxiety, depression and different traditional chinese medicine syndromes types in patients with diarrhea-predominant irritable bowel syndrome (IBS-D). Methods: 121 IBS-D patients and 100 healthy volunteers who underwent physical examinations were selected as the control group. IBS-D patients were divided into IBS-D with depression group and IBS-D without depression group based on their depression status; and according to the anxiety status, they were divided into IBS-D with anxiety group and IBS-D without anxiety group. Detected serum IDO levels and calculateed IDO activation index, and explore the relationship between IDO levels, IDO activation index, and different traditional chinese medicine syndrome types in IBS-D patients were analyze. Results: The serum IDO levels and IDO activation index of IBS-D group were higher than those of the control group (P<0.05). The serum IDO levels and IDO activation index in the IBS-D with depression group were higher than those in the IBS-D without depression group(P<0.05). The serum IDO levels and IDO activation index in the IBS-D with anxiety group were higher than those in the IBS-D without anxiety group (P<0.05). The serum IDO levels of liver stagnation and spleen deficiency type, spleen and stomach damp heat type, and spleen deficiency wet block type were higher than those of the control group (P<0.05), and the IDO activation index of splenic kidney yang deficiency type, liver stagnation and spleen deficiency type, spleen deficiency wet block type and spleen and stomach damp heat type were higher than that of the control group(P<0.05). The serum IDO level was positively correlated with liver stagnation and spleen deficiency type, and negatively correlated with splenic kidney yang deficiency type and intestinal dryness-heat type (P<0.05). The IDO activation index was positively correlated with liver stagnation and spleen deficiency type, and negatively correlated with intestinal dryness-heat type and spleen deficiency wet block type(P<0.05). Conclusion: The elevated levels of serum IDO and IDO activation in IBS-D patients are related to their anxiety, depression, and traditional chinese medicine syndrome types. Serum IDO levels and activation levels can provide reference for clinical treatment of IBS-D based on syndrome differentiation. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
