| 张嘉诚,王金文,杜 鹏,蒋富强,解 鹏,张 哲,杨 剑,马军朋.血清miR-202、miR-34a表达与原发性肝癌患者TACE术后
发生医院感染的临床研究[J].,2024,(22):4262-4264 |
| 血清miR-202、miR-34a表达与原发性肝癌患者TACE术后
发生医院感染的临床研究 |
| Clinical Study on the Expression of Serum miR-202 and miR-34a and Nosocomial Infection in Patients with Primary Liver Cancer after TACE |
| 投稿时间：2024-06-05 修订日期：2024-07-09 |
| DOI：10.13241/j.cnki.pmb.2024.22.017 |
| 中文关键词: 原发性肝癌 miR-202 miR-34a 肝动脉灌注化疗栓塞术 医院感染 |
| 英文关键词: Primary liver cancer miR-202 miR-34a Transcatheter arterial chemoembolization Nosocomial infection |
| 基金项目:北京市科学技术委员会"首都临床特色应用研究"项目（Z171100000417049） |
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| 中文摘要: |
| 摘要 目的：分析血清微小核糖核酸（miR）-202、miR-34a表达与原发性肝癌（PLC）患者行肝动脉灌注化疗栓塞术（TACE）术后发生医院感染的关系。方法：选取接受TACE术的975例PLC患者，按照TACE术后是否发生医院感染分为感染组（n=80）、未感染组（n=895），对比两组患者血清miR-202、miR-34a相对表达量及临床资料，多因素Logistic回归模型分析影响因素，受试者工作特征（ROC）曲线分析预测价值。结果：年龄≥60岁、合并糖尿病、合并腹水、介入操作时间≥120 min、未预防性使用抗菌药物是影响PLC患者TACE术后医院感染的危险因素（P＜0.05），血清miR-202、miR-34a相对表达量上升是保护因素（P＜0.05）。血清miR-202、miR-34a二者联合预测PLC患者TACE术后医院感染高于单一预测。结论：PLC患者TACE术后医院感染患者血清miR-202、miR-34a呈低表达，且二者联合可有效预测TACE术后医院感染的发生。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the relationship between serum microRNA (miR) -202, miR-34a expression and nosocomial infection in patients with primary liver cancer(PLC) after transcatheter arterial chemoembolization (TACE). Methods: 975 patients with PLC who underwent TACE were selected. Patients were divided into infection group (n=80) and uninfected group (n=895) according to whether nosocomial infection occurred after TACE, the relative expression levels of serum miR-202 and miR-34a and clinical data were compared between two groups, the influencing factors were analyzed by multivariate Logistic regression model, the value of were analyzed by receiver operating characteristic (ROC) curve. Results: The age≥60 years old, diabetes mellitus, ascites, interventional operation time ≥120 min, and non-prophylactic use of antibiotics were risk factors for nosocomial infection in patients with PLC after TACE (P<0.05), the increase in the relative expression of serum miR-202 and miR-34a were protective factor (P<0.05). The combined prediction of serum miR-202 and miR-34a for postoperative nosocomial infection in PLC patients with TACE was higher than that of single prediction. Conclusion: The expression of serum miR-202 and miR-34a in patients with PLC after TACE are low, and their combination can effectively predict the occurrence of nosocomial infection after TACE. |
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