| 曾玉花,田 迪,林 以,刘丽兰,任玉钢.不同强度有氧运动对急性心肌梗死后心功能不全患者心肺功能、血管内皮功能及生活质量的影响[J].,2024,(18):3549-3553 |
| 不同强度有氧运动对急性心肌梗死后心功能不全患者心肺功能、血管内皮功能及生活质量的影响 |
| Effects of Different Intensity Aerobic Exercise on Cardiopulmonary Function, Vascular Endothelial Function and Quality of Life in Patients with Cardiac Dyfunction after Acute Myocardial Infarction |
| 投稿时间：2023-12-26 修订日期：2024-01-23 |
| DOI：10.13241/j.cnki.pmb.2024.18.028 |
| 中文关键词: 不同强度 有氧运动 急性心肌梗死 心功能不全 心肺功能 血管内皮功能 生活质量 |
| 英文关键词: Different intensity Aerobic exercise Acute myocardial infarction Cardiac dyfunction Cardiopulmonary function Vascular endothelial function Quality of life |
| 基金项目:湖南省中医药管理局项目资助课题（201953） |
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| 中文摘要: |
| 摘要 目的：探讨不同强度有氧运动对急性心肌梗死（AMI）后心功能不全（CD）患者心肺功能、血管内皮功能及生活质量的影响，以期为AMI后CD的临床干预提供指导。方法：选取2022年5月到2023年5月本院收治的AMI后CD患者共计135例进行前瞻性研究，以随机数字表法分成A组（n=45）、B组（n=45）、C组（n=45），A组给予常规治疗，B组在A组基础上实施中强度有氧运动，C组在A组基础上实施高强度间歇有氧运动，比较三组心功能指标、肺功能、血管内皮功能、生活质量。结果：干预后三组左心室收缩末期内径（LVESD）、左心室舒张末期内径（LVEDD）下降（P<0.05），左心室射血分数（LVEF）升高（P<0.05），B组、C组LVESD、LVEDD较A组更低（P<0.05），LVEF更高（P<0.05），C组LVESD、LVEDD较B组更低（P<0.05），LVEF更高（P<0.05）。干预后三组用力肺活量（FVC）、第1秒用力呼吸容积（FEV1）与FVC比值（FEV1/FVC）、最大自主分钟通气量（MVV）升高（P<0.05），B组、C组较A组更高（P<0.05），C组较B组更高（P<0.05）。干预后三组内皮素-1（ET-1）下降（P<0.05），一氧化氮（NO）、脑动脉血流介导的内皮依赖性舒张功能（FMD）、硝酸甘油介导的非内皮依赖性舒张功能（NMD）升高（P<0.05），B组、C组ET-1较A组更低（P<0.05），NO、FMD、NMD更高（P<0.05），C组ET-1较B组更低（P<0.05），NO、FMD、NMD更高（P<0.05）。干预后三组西雅图心绞痛量表（SAQ）评分升高（P<0.05），B组、C组较A组更高（P<0.05），C组较B组更高（P<0.05）。结论：AMI后CD患者实施高强度间歇有氧运动的效果较好，能够有效改善心肺功能、血管内皮功能，提高生活质量，值得临床借鉴推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of different intensity aerobic exercise on cardiopulmonary function, vascular endothelial function and quality of life in patients with cardiac dyfunction (CD) after acute myocardial infarction (AMI), in order to provide guidance for clinical intervention of CD after AMI. Methods: A total of 135 patients with CD after AMI admitted to our hospital from May 2022 to May 2023 were selected for prospective study, and divided into group A (n=45), group B (n=45) and group C (n=45) by random number table method. Group A received conventional treatment, and group B received moderate intensity aerobic exercise on the basis of group A. Group C performed high intensity intermittent aerobic exercise on the basis of group A, and compared the cardiac function index, lung function, vascular endothelial function and quality of life of the three groups. Results: After intervention, left ventricular end systolic diameter(LVESD) and left ventricular end diastolic diameter (LVEDD) in the three groups were decreased (P<0.05), and left ventricular ejection fraction(LVEF) was increased (P<0.05), LVESD and LVEDD in groups B and C were lower than those in group A (P<0.05), and LVEF was higher (P<0.05), LVESD and LVEDD of group C were lower than those of group B (P<0.05), and the LVEF of group C was higher than that of group B(P<0.05). After the intervention, the forced vital capacity (FVC), the forced expira-tory volume in 1 second(FEV1) /FVC (FEV1/FVC), and the maximal voluntary ventilation (MVV) in the three groups were increased (P<0.05), and those in groups B and C were higher than those in group A(P<0.05), and those in group C were higher than those in group B (P<0.05). After intervention, endothelin-1 (ET-1) decreased in the three groups (P<0.05), nitric oxide (NO), endothelium mediated flow-mediated dilation(FMD) and nitroglycerin mediated nitroglycerin-mediateddilation(NMD) increased(P<0.05), and ET-1 in groups B and C was lower than that in group A (P<0.05). NO, FMD and NMD were higher (P<0.05), ET-1 in group C was lower than that in group B (P<0.05), and NO, FMD and NMD were higher (P<0.05). After the intervention, the score of Seattle Angina Questionnaire(SAQ) in the three groups was increased (P<0.05), and the score in group B and C was higher than that in group A(P<0.05), and the score in group C was higher than that in group B(P<0.05). Conclusion: The effect of high intensity intermittent aerobic exercise in CD patients after AMI is good, which can effectively improve the cardiopulmonary function, vascular endothelial function, and improve the quality of life, which is worthy of clinical reference and application. |
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