| 潘 青,朱晓晴,毕言雪,吕晓红,亓华新.QTc、Tp-Tec间期联合血清BNP、Gal-3预测急性心肌梗死后室性心律失常的临床研究[J].,2024,(17):3396-3400 |
| QTc、Tp-Tec间期联合血清BNP、Gal-3预测急性心肌梗死后室性心律失常的临床研究 |
| Clinical Study of QTc,Tp-Tec Interval Combined with Serum BNP and Gal-3 in Predicting Ventricular Arrhythmia after Acute Myocardial Infarction |
| 投稿时间：2024-01-26 修订日期：2024-02-19 |
| DOI：10.13241/j.cnki.pmb.2024.17.038 |
| 中文关键词: QTc Tp-Tec BNP Gal-3 急性心肌梗死 室性心律失常 |
| 英文关键词: QTc Tp-Tec BNP Gal-3 Acute myocardial infarction Ventricular arrhythmia |
| 基金项目:山东省重点研发计划项目（2016ZRA01076） |
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| 中文摘要: |
| 摘要 目的：研究按心率校正的QT（QTc）、按心率校正的Tp-Te（Tp-Tec）间期联合血清脑钠肽（BNP）、半乳糖凝集素-3（Gal-3）预测急性心肌梗死（AMI）后室性心律失常（VA）的临床作用。方法：选取从2023年1月到7月在济南市人民医院接受治疗的AMI患者182例作为研究对象。根据住院期间是否发生VA进行分组，其中存在VA的71例患者作为观察组，不存在VA的111例患者作为对照组。检测并对比两组QTc、Tp-Tec以及血清BNP、Gal-3水平。多因素Logistic回归分析AMI后并发VA的影响因素，受试者工作特征（ROC）曲线分析QTc、Tp-Tec联合血清BNP、Gal-3对 AMI后并发VA的预测效能。结果：观察组QTc、Tp-Tec以及血清BNP、Gal-3水平较对照组更高（P＜0.05）。多因素Logistic回归分析发现QTc、Tp-Tec、BNP及Gal-3升高及血管病变支数为双支/多支为AMI后并发VA的危险因素。ROC曲线分析发现，QTc、Tp-Tec、BNP及Gal-3联合检测对AMI后并发VA的预测效能最佳，其中AUC为0.864，敏感度为92.50%，特异度为79.83%，约登指数为0.723。结论：AMI后并发VA患者的QTc、Tp-Tec、BNP及Gal-3水平升高，且是AMI后并发VA的危险因素。QTc、Tp-Tec、BNP及Gal-3联合检测对AMI后VA具有较好的预测价值。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical effect of heart rate corrected QT (QTc), heart rate corrected Tp-Te (Tp-Tec) interval combined with serum brain natriuretic peptide (BNP) and galectin-3 (Gal-3) in predicting ventricular arrhythmia (VA) after acute myocardial infarction (AMI). Methods: 182 AMI patients who were treated in Jinan People's Hospital from January to July 2023 were selected as study subjects. Group based on whether VA occurred during hospitalization, with 71 patients with VA as the observation group and 111 patients without VA as the control group. The levels of QTc, Tp-Tec, serum BNP and Gal-3 were detected and compared between two groups. The influencing factors of VA after AMI were analyzed by multivariate Logistic regression analysis, the predictive efficacy of QTc, Tp-Tec combine with serum BNP and Gal-3 on VA after AMI were analyzed by receiver operating characteristic (ROC) curve. Results: The levels of QTc, Tp-Tec, serum BNP and Gal-3 in observation group were higher than those in control group (P<0.05). Multivariate Logistic regression analysis showed that elevated QTc, Tp-Tec, BNP and Gal-3 and double/multiple vascular lesions were risk factors for VA after AMI. ROC curve analysis showed that, the combined detection of QTc, Tp-Tec, BNP and Gal-3 had the best predictive efficacy for VA after AMI, with AUC of 0.864, sensitivity of 92.50%, specificity of 79.83% and Youden index of 0.723. Conclusion: The levels of QTc, Tp-Tec, BNP and Gal-3 in VA patients after AMI are increase, and are risk factors for VA after AMI. The combine detection of QTc, Tp-Tec, BNP and Gal-3 has a good predictive value for VA after AMI. |
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