| 胡义萍,王 芳,李 迅,胡 新,李家飞.老年慢性阻塞性肺病患者睡眠障碍发生情况及与认知功能损害的相关性分析[J].,2024,(17):3391-3395 |
| 老年慢性阻塞性肺病患者睡眠障碍发生情况及与认知功能损害的相关性分析 |
| Occurrence of Sleep Disorders in Elderly Patients with Chronic Obstructive Pulmonary Disease and its Correlation with Cognitive Impairment |
| 投稿时间：2023-11-28 修订日期：2023-12-23 |
| DOI：10.13241/j.cnki.pmb.2024.17.037 |
| 中文关键词: 慢性阻塞性肺病 睡眠障碍 认知功能 相关性 |
| 英文关键词: Chronic obstructive pulmonary disease Sleep disorder Cognitive function Correlation |
| 基金项目:安徽医科大学校基金资助项目（2023XKJ208） |
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| 中文摘要: |
| 摘要 目的：观察老年慢性阻塞性肺病（COPD）患者睡眠障碍发生情况及与认知功能损害的相关性。方法：选取2021年1月~2022年12月我院诊治的老年COPD患者100例，根据匹兹堡睡眠指数量表（PSQI）评分，将研究对象分为睡眠障碍组与无睡眠障碍组，采用简易精神状态检查量表（MMSE）评估两组患者的认知功能，选取两组基线资料及MMSE评分为自变量，采用单因素与多因素Logistic分析睡眠障碍的影响因素，并分析PSQI评分与MMSE评分之间的相关性。结果：100例老年COPD患者中，32例（32%）发生睡眠障碍。与无睡眠障碍组患者比较，睡眠障碍组PSQI各指标得分均较高，且睡眠障碍组的PSQI总分为（7.48±1.81）分，高于无睡眠障碍组的（6.02±0.74）分（P<0.05）。单因素分析结果显示，睡眠障碍组MMSE各维度评分及MMSE总分均低于无睡眠障碍组，病程≥10年、呼吸困难分级≥3级的比例则高于无睡眠障碍组（P<0.05）。多因素Logistic回归分析显示，病程、呼吸困难分级、MMSE评分是COPD患者发生睡眠障碍的独立危险因素（P＜0.05）。pearson相关性分析结果显示，COPD患者PSQI评分与MMSE评分呈负相关，与病程、呼吸困难分级成正相关（P＜0.05）。结论：老年COPD患者中睡眠障碍的发生风险较高，其中病程、呼吸困难分级、MMSE评分均为睡眠障碍的影响因素，且患者睡眠质量与认知功能损害程度密切相关，建议临床予以重点关注。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the occurrence of sleep disorders in elderly patients with chronic obstructive pulmonary disease (COPD) and its correlation with cognitive impairment. Methods: A total of 100 elderly patients with COPD admitted to the hospital from January 2021 to December 2022 were selected. According to the Pittsburgh Sleep Quality Index (PSQI) score, the subjects were divided into sleep disorder group and non-sleep disorder group. Cognitive function in the two groups was evaluated with the Mini Mental State Examination (MMSE). Baseline data and MMSE scores of the two groups were taken as independent variables. Univariate analysis and multivariate logistic analysis were conducted to identify the influencing factors of sleep disorders. The correlation between PSQI score and MMSE score was analyzed. Results: Of the 100 elderly patients with COPD, 32 (32%) had sleep disorders. Compared with the non-sleep disorder group, the sleep disorder group had higher PSQI scores. The total PSQI score of the sleep disorder group was (7.48±1.81), higher than (6.02±0.74) of the non-sleep disorder group (P<0.05). Univariate analysis showed that the MMSE scores of different dimensions and the total MMSE score of the sleep disorder group were lower than those of the non-sleep disorder group. The proportions of patients with course of disease ≥ 10 years and dyspnea grade ≥ 3 were higher than those in the non-sleep disorder group (P<0.05). Multivariate logistic regression analysis showed that course of disease, dyspnea grade and MMSE score were independent risk factors for sleep disorders in patients with COPD (P<0.05). Pearson correlation analysis found that PSQI score was negatively correlated with MMSE score in patients with COPD, while the PSQI score is positively correlated with the course of the disease and the grading of dyspnea (P<0.05). Conclusion: The risk of sleep disorders in elderly patients with COPD is high. The course of disease, dyspnea grade, and MMSE score are influencing factors of sleep disorders. In addition, the patients' sleep quality is closely related to the degree of cognitive impairment, which deserves attention in clinical practice. |
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