| 马 利,马政权,马晓瑞,李 茉,马楼艳,翟佳佳.维生素D受体基因多态性FokI位点与老年2型糖尿病的相关性研究[J].,2024,(17):3348-3353 |
| 维生素D受体基因多态性FokI位点与老年2型糖尿病的相关性研究 |
| A Study on the Relationship between Gene Polymorphism FokI of Vitamin D Receptor and in Elderly with Type 2 Diabetes |
| 投稿时间：2024-04-10 修订日期：2024-05-09 |
| DOI：10.13241/j.cnki.pmb.2024.17.029 |
| 中文关键词: FokI位点 维生素D受体 2型糖尿病 老年 |
| 英文关键词: FokI Vitamin D receptor Type 2 diabetes Elderly |
| 基金项目:陕西省自然科学项目（2020JQ-960）；西安市局级科研项目（J201702014） |
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| 中文摘要: |
| 摘要 目的：探讨维生素D受体（vitamin D receptor，VDR）基因（删除基因）FokI位点基因型及等位基因频率分布与老年2型糖尿病（type 2 diabetes，T2DM）的相关性。方法：选取2022年1月-2023年12月在西安市第九医院老年病科、全科医学科、内分泌科就诊的年龄>60岁的2型糖尿病患者110例及同期112名体检健康者为研究对象，应用电化学发光法检测其血浆25-羟基维生素D水平，探针法联合测序法（测序法检验结果）分析其VDR基因（删除基因）FokI位点基因多态性分布。结果：在T2DM组和对照组一般资料的比较结果提示：体重、体重指数（body mass index，BMI）、空腹血糖（Fasting blood glucose，FBG）、高密度脂蛋白胆固醇（high-density lipoprotein cholesterol，HDL-C）、低密度脂蛋白胆固醇（low-density lipoprotein cholesterol，LDL-C）、维生素D水平（Vitamin D level）两组间比较差异有统计学意义（P<0.05）。多因素logistic回归分析结果提示：HDL-C可能是T2DM的保护性因素[OR=0.060，95%CI(0.019-0.193)，P<0.05]。维生素D可能是T2DM的保护性因素[OR=0.969，95%CI(0.939-0.999)，P<0.05]，VDR-FokI CC基因型可能是T2DM的保护性因素[OR=0.383，95%CI(0.150-0.982)，P<0.05]。结论：（1）HDL-C及维生素D可能是T2DM保护性因素。（2）VDR-FokI位点CC基因型可能是T2DM发病的保护性因素。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the relationship between vitamin D receptor (vitamin D receptor, VDR) FokI genetypes, allele frequency and Type 2 diabetes (T2DM) in elderly. Methods: Included 110 patients with type 2 diabetes, over the age of 60, and 112 healthy individuals who underwent physical examinations at the departments of Geriatrics, General Medicine, and Endocrinology of Xi'an Ninth Hospital from January 2022 to December 2023. Plasma levels of 25-hydroxyvitamin D were measured using the electrochemiluminescence immunoassay (ECLIA) method. Additionally, the distribution of gene polymorphisms at the FokI site of the vitamin D receptor (VDR) gene was analyzed using a probe-based method combined with sequencing. Results: A comparative analysis of general information between patients with type 2 diabetes mellitus (T2DM) and a control group revealed significant differences in body weight, body mass index (BMI), fasting blood glucose (FBG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and vitamin D levels (P<0.05). Multivariate logistic regression analysis indicated that HDL-C may be a protective factor for T2DM, with an odds ratio (OR) of 0.060 and a 95% confidence interval (CI) of 0.019 to 0.193 (P<0.05). Additionally, vitamin D may be a protective factor for T2DM, with an OR of 0.969 and a 95% CI of 0.939 to 0.999 (P<0.05). Furthermore, the CC genotype of the vitamin D receptor (VDR) FokI locus was identified as a potential protective factor against T2DM, with an OR of 0.383 and a 95% CI of 0.150 to 0.982 (P<0.05). Conclusion: (1) HDL-C and Vitamin D may be a protective factor for T2DM; (2) The CC genotype of FokI may be a protective factor for T2DM. |
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