| 褚夫政,徐义强,汪敏行,邓李轶,高文昌.预后营养指数、D-二聚体/纤维蛋白原比值与脑胶质瘤患者恶性程度和术后复发的关系[J].,2024,(17):3306-3309 |
| 预后营养指数、D-二聚体/纤维蛋白原比值与脑胶质瘤患者恶性程度和术后复发的关系 |
| Relationship between Prognostic Nutritional Index, D-Dimer/Fibrinogen Ratio and Malignant Degree and Postoperative Recurrence in Glioma Patients |
| 投稿时间：2024-03-05 修订日期：2024-03-27 |
| DOI：10.13241/j.cnki.pmb.2024.17.021 |
| 中文关键词: 脑胶质瘤 预后营养指数 D-二聚体/纤维蛋白原比值 恶性程度 复发 |
| 英文关键词: Glioma Prognostic nutritional index D-dimer/fibrinogen ratio Malignant degree Recurrence |
| 基金项目:江苏省自然科学基金面上项目（BK20181152） |
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| 中文摘要: |
| 摘要 目的：探讨预后营养指数（PNI）、D-二聚体/纤维蛋白原比值（DFR）与脑胶质瘤患者恶性程度和术后复发的关系。方法：选择2019年6月至2022年6月我院收治的132例脑胶质瘤患者，根据世界卫生组织（WHO）分级将患者分为低级别组（Ⅰ+Ⅱ级，97例）和高级别组（Ⅲ+Ⅳ级，35例）。所有患者接受肿瘤切除术，术前检测血清白蛋白、淋巴细胞计数、D-二聚体、纤维蛋白原水平，计算PNI和DFR，术后随访统计复发情况，分析PNI和DFR与脑胶质瘤患者术后复发的关系。结果：高级别组PNI低于低级别组（P＜0.05），DFR高于低级别组（P＜0.05）。术后中位随访25（8-44）月，失访2例，随访期间复发33例。复发组PNI低于未复发组（P＜0.05），DFR高于未复发组（P＜0.05）。多因素Logistic回归显示WHO分级高级别，高DFR是脑胶质瘤患者术后复发的危险因素（P＜0.05），高PNI是保护因素（P＜0.05）。结论：高WHO分级和术后复发的脑胶质瘤患者术前PNI降低，DFR升高，DFR升高是其术后复发的危险因素，PNI升高是保护因素。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between prognostic nutritional index (PNI), D-dimer/fibrinogen ratio (DFR) and malignant degree and postoperative recurrence in glioma patients. Methods: 132 glioma patients admitted to our hospital from June 2019 to June 2022 were selected, the patients were divided into low-level group (grade I+II, 97 cases) and high-level group (grade III+IV, 35 cases) according to the World Health Organization (WHO) classification. All patients underwent tumor resection, serum albumin, lymphocyte count, D-dimer and fibrinogen levels were measured before operation, PNI and DFR were calculated, postoperative recurrence was followed up, the relationship between PNI and DFR and postoperative recurrence of glioma patients was analyzed. Results: PNI in high-level group was lower than that in low-level group (P<0.05), and DFR was higher than that in low-level group (P<0.05). After a median follow-up of 25(8-44) months, 2 cases were lost to follow-up, and 33 cases recurred during the follow-up period. PNI in recurrence group was lower than that in non-recurrence group (P<0.05), and DFR was higher than that in non-recurrence group (P<0.05). Multivariate Logistic regression showed that high WHO grade, high DFR were risk factors for postoperative recurrence of glioma patients (P<0.05), and high PNI was a protective factor (P<0.05). Conclusion: Preoperative PNI decrease and DFR increase in patients with high WHO grade and postoperative recurrence of glioma, increase DFR is a risk factor for postoperative recurrence, and increase PNI is a protective factor. |
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